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Medical oncologists' perspectives of the Veterans Affairs National Precision Oncology Program.
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- Author(s): Vashistha V;Vashistha V;Vashistha V;Vashistha V; Poonnen PJ; Poonnen PJ; Poonnen PJ; Poonnen PJ; Snowdon JL; Snowdon JL; Skinner HG; Skinner HG; McCaffrey V; McCaffrey V; Spector NL; Spector NL; Spector NL; Spector NL; Hintze B; Hintze B; Duffy JE; Duffy JE; Weeraratne D; Weeraratne D; Jackson GP; Jackson GP; Jackson GP; Kelley MJ; Kelley MJ; Kelley MJ; Kelley MJ; Patel VL; Patel VL
- Source:
PloS one [PLoS One] 2020 Jul 24; Vol. 15 (7), pp. e0235861. Date of Electronic Publication: 2020 Jul 24 (Print Publication: 2020).- Publication Type:
Journal Article; Research Support, Non-U.S. Gov't- Language:
English - Source:
- Additional Information
- Source: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE
- Publication Information: Original Publication: San Francisco, CA : Public Library of Science
- Subject Terms: Health Knowledge, Attitudes, Practice* ; United States Department of Veterans Affairs*; High-Throughput Nucleotide Sequencing/*standards ; Neoplasms/*genetics ; Oncologists/*psychology ; Sequence Analysis, DNA/*standards; Adult ; Early Detection of Cancer/standards ; Female ; Genetic Testing/standards ; Humans ; Male ; Middle Aged ; Neoplasms/diagnosis ; Precision Medicine/standards ; State Health Plans ; Surveys and Questionnaires ; United States
- Abstract: Background: To support the rising need for testing and to standardize tumor DNA sequencing practices within the U.S. Department of Veterans Affairs (VA)'s Veterans Health Administration (VHA), the National Precision Oncology Program (NPOP) was launched in 2016. We sought to assess oncologists' practices, concerns, and perceptions regarding Next-Generation Sequencing (NGS) and the NPOP.
Materials and Methods: Using a purposive total sampling approach, oncologists who had previously ordered NGS for at least one tumor sample through the NPOP were invited to participate in semi-structured interviews. Questions assessed the following: expectations for the NPOP, procedural requirements, applicability of testing results, and the summative utility of the NPOP. Interviews were assessed using an open coding approach. Thematic analysis was conducted to evaluate the completed codebook. Themes were defined deductively by reviewing the direct responses to interview questions as well as inductively by identifying emerging patterns of data.
Results: Of the 105 medical oncologists who were invited to participate, 20 (19%) were interviewed from 19 different VA medical centers in 14 states. Five recurrent themes were observed: (1) Educational Efforts Regarding Tumor DNA Sequencing Should be Undertaken, (2) Pathology Departments Share a Critical Role in Facilitating Test Completion, (3) Tumor DNA Sequencing via NGS Serves as the Most Comprehensive Testing Modality within Precision Oncology, (4) The Availability of the NPOP Has Expanded Options for Select Patients, and (5) The Completion of Tumor DNA Sequencing through the NPOP Could Help Improve Research Efforts within VHA Oncology Practices.
Conclusion: Medical oncologists believe that the availability of tumor DNA sequencing through the NPOP could potentially lead to an improvement in outcomes for veterans with metastatic solid tumors. Efforts should be directed toward improving oncologists' understanding of sequencing, strengthening collaborative relationships between oncologists and pathologists, and assessing the role of comprehensive NGS panels within the battery of precision tests.
Competing Interests: In regard to potential competing interests, authors JLS, VM, DW, and GPJ are employed by IBM Watson Health. In addition, author HGS was previously employed by IBM Watson Health and author VLP is a consultant for IBM Watson Health. As mentioned, the commercial interest did not have any additional role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript. This does not alter our adherence to PLOS ONE policies on sharing data and materials. - References: J Genet Couns. 2017 Aug;26(4):878-886. (PMID: 28091859)
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NPJ Precis Oncol. 2018 Apr 16;2:11. (PMID: 30202789) - Publication Date: Date Created: 20200725 Date Completed: 20200915 Latest Revision: 20200915
- Publication Date: 20240104
- Accession Number: PMC7380614
- Accession Number: 10.1371/journal.pone.0235861
- Accession Number: 32706774
- Source:
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