Biphasic Squamoid Alveolar Renal Cell Carcinoma of the Kidney Involved by Atypical CD5-Positive B-Cells.

Publisher: Sage Publications Country of Publication: United States NLM ID: 9314927 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1940-2465 (Electronic) Linking ISSN: 10668969 NLM ISO Abbreviation: Int J Surg Pathol Subsets: MEDLINE

Publication: Thousand Oaks, CA : Sage Publications
Original Publication: Naperville, IL : Churchill Livingstone, c1993-

B-Lymphocytes/*pathology ; Carcinoma, Renal Cell/*diagnosis ; Kidney/*pathology ; Kidney Neoplasms/*diagnosis; Aged ; B-Lymphocytes/metabolism ; Biomarkers, Tumor/analysis ; Biomarkers, Tumor/metabolism ; CD5 Antigens/analysis ; CD5 Antigens/metabolism ; Carcinoma, Renal Cell/surgery ; Diagnosis, Differential ; Emperipolesis ; Humans ; Incidental Findings ; Kidney/cytology ; Kidney/diagnostic imaging ; Kidney/surgery ; Kidney Neoplasms/pathology ; Kidney Neoplasms/surgery ; Male ; Nephrectomy ; Tomography, X-Ray Computed

Biphasic squamoid alveolar renal cell carcinoma (BSARCC) is a recently described kidney cancer entity with <60 published cases so far. Some unique features of BSARCC include distinct squamoid and alveolar morphology forming glomeruloid configurations and 2 types of tumor cells with different immunoprofiles. Although the mechanism is unknown, neutrophils and cellular materials engulfed by larger tumor cells (described as "emperipolesis") are observed in all reported cases including the current one. In this article, we report a case of a 70-year-old man who presented with an incidental renal mass during workup for immunoglobulin M monoclonal gammopathy of unknown significance and cold agglutinin autoimmune hemolytic anemia. A detailed pathologic evaluation and immunohistochemical studies revealed BSARCC colliding with atypical CD5+ monoclonal B-cells.

Keywords: atypical CD5-positive B-cells; biphasic squamoid alveolar renal cell carcinoma

0 (Biomarkers, Tumor)
0 (CD5 Antigens)

Date Created: 20200910 Date Completed: 20210907 Latest Revision: 20210907

20240105

10.1177/1066896920957089

32909465