Pseudomonas aeruginosa bloodstream infection at a tertiary referral hospital for children.

Publisher: BioMed Central Country of Publication: England NLM ID: 100968551 Publication Model: Electronic Cited Medium: Internet ISSN: 1471-2334 (Electronic) Linking ISSN: 14712334 NLM ISO Abbreviation: BMC Infect Dis Subsets: MEDLINE

Original Publication: London : BioMed Central, [2001-

Pseudomonas Infections/*diagnosis ; Pseudomonas aeruginosa/*isolation & purification; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/therapeutic use ; Child ; Child, Preschool ; Drug Resistance, Bacterial/drug effects ; Female ; Hospitals, Pediatric ; Humans ; Infant ; Intensive Care Units ; Male ; Microbial Sensitivity Tests ; Pseudomonas Infections/drug therapy ; Pseudomonas Infections/mortality ; Pseudomonas aeruginosa/drug effects ; Retrospective Studies ; South Africa/epidemiology ; Survival Rate ; Tertiary Care Centers

Background: This study describes the disease burden, clinical characteristics, antibiotic management, impact of multidrug resistance and outcome of Pseudomonas aeruginosa bloodstream infection (PABSI) among children admitted to a tertiary referral hospital for children in Cape Town, South Africa.
Methods: A retrospective descriptive study was conducted at a paediatric referral hospital in Cape Town, South Africa. Demographic and clinical details, antibiotic management and patient outcome information were extracted from medical and laboratory records. Antibiotic susceptibility results of identified organisms were obtained from the National Health Laboratory Service database.
Results: The incidence risk of PABSI was 5.4 (95% CI: 4.34-6.54) PABSI episodes / 10,000 hospital admissions and the most common presenting feature was respiratory distress, 34/91 (37.4%). Overall, 69/91 (75.8%) of the PA isolates were susceptible to all antipseudomonal antibiotic classes evaluated. Fifty (54.9%) of the PABSI episodes were treated with appropriate empiric antibiotic therapy. The mortality rate was 24.2% and in multivariable analysis, empiric antibiotic therapy to which PA isolates were not susceptible, infections present on admission, and not being in the intensive care unit at the time that PABSI was diagnosed were significantly associated with 14-day mortality.
Conclusions: PABSI caused appreciable mortality, however, appropriate empiric antibiotic therapy was associated with reduced 14-day mortality.

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Keywords: Children; Pseudomonas aeruginosa bloodstream infection; Sub-Saharan Africa

0 (Anti-Bacterial Agents)

Date Created: 20201008 Date Completed: 20201019 Latest Revision: 20201019

20240105

PMC7541237

10.1186/s12879-020-05437-1

33028225