Metabolic and Redox Regulation of Cardiovascular Stem Cell Biology and Pathology.

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  • Author(s): Dudek J;Dudek J; Kutschka I; Kutschka I; Maack C; Maack C; Maack C
  • Source:
    Antioxidants & redox signaling [Antioxid Redox Signal] 2021 Jul 20; Vol. 35 (3), pp. 163-181. Date of Electronic Publication: 2020 Dec 31.
  • Publication Type:
    Journal Article; Research Support, Non-U.S. Gov't; Review
  • Language:
    English
  • Additional Information
    • Source:
      Publisher: Mary Ann Liebert, Inc Country of Publication: United States NLM ID: 100888899 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1557-7716 (Electronic) Linking ISSN: 15230864 NLM ISO Abbreviation: Antioxid Redox Signal Subsets: MEDLINE
    • Publication Information:
      Original Publication: Larchmont, NY : Mary Ann Liebert, Inc., 1999-
    • Subject Terms:
    • Abstract:
      Significance: Cardiovascular stem cells are important for regeneration and repair of damaged tissue. Recent Advances: Pluripotent stem cells have a unique metabolism, which is adopted for their energetic and biosynthetic demand as rapidly proliferating cells. Stem cell differentiation requires an exceptional metabolic flexibility allowing for metabolic remodeling between glycolysis and oxidative phosphorylation. Critical Issues: Respiration is associated with the generation of reactive oxygen species (ROS) by the mitochondrial respiratory chain. But also the membrane-bound protein nicotinamide adenine dinucleotide phosphate oxidase (NADPH oxidase, NOX) contributes to ROS levels. ROS not only play a significant role in stem cell differentiation and tissue renewal but also cause senescence and contribute to tissue aging. Future Directions: For utilization of stem cells in therapeutic approaches, a deep understanding of the molecular mechanisms how metabolism and the cellular redox state regulate stem cell differentiation is required. Modulating the redox state of stem cells using antioxidative agents may be suitable to enhance activity of endothelial progenitor cells. Antioxid. Redox Signal. 35, 163-181.
    • Contributed Indexing:
      Keywords: heart diseases; metabolism; mitochondria; reactive oxygen species; respiratory chain; stem cells
    • Accession Number:
      0 (Reactive Oxygen Species)
      S88TT14065 (Oxygen)
    • Publication Date:
      Date Created: 20201030 Date Completed: 20220307 Latest Revision: 20220307
    • Publication Date:
      20240105
    • Accession Number:
      10.1089/ars.2020.8201
    • Accession Number:
      33121253