Fatal Case of Chronic Jamestown Canyon Virus Encephalitis Diagnosed by Metagenomic Sequencing in Patient Receiving Rituximab.

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  • Additional Information
    • Source:
      Publisher: National Center for Infectious Diseases, Centers for Disease Control and Prevention (CDC) Country of Publication: United States NLM ID: 9508155 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1080-6059 (Electronic) Linking ISSN: 10806040 NLM ISO Abbreviation: Emerg Infect Dis Subsets: MEDLINE
    • Publication Information:
      Original Publication: Atlanta, GA : National Center for Infectious Diseases, Centers for Disease Control and Prevention (CDC), [1995-
    • Subject Terms:
      Encephalitis Virus, California* ; Encephalitis, California*; Antibodies, Viral ; Humans ; Male ; Metagenome ; Metagenomics ; Middle Aged ; Rituximab
    • Abstract:
      A 56-year-old man receiving rituximab who had months of neurologic symptoms was found to have Jamestown Canyon virus in cerebrospinal fluid by clinical metagenomic sequencing. The patient died, and postmortem examination revealed extensive neuropathologic abnormalities. Deep sequencing enabled detailed characterization of viral genomes from the cerebrospinal fluid, cerebellum, and cerebral cortex.
    • References:
      Nat Rev Microbiol. 2014 Oct;12(10):673-85. (PMID: 25198140)
      Viruses. 2019 Aug 14;11(8):. (PMID: 31416162)
      N Engl J Med. 2019 Jun 13;380(24):2327-2340. (PMID: 31189036)
      MMWR Morb Mortal Wkly Rep. 2018 Oct 19;67(41):1137-1142. (PMID: 30335737)
      Emerg Microbes Infect. 2020 Dec;9(1):903-912. (PMID: 32302268)
      Emerg Infect Dis. 2018 Jan;24(1):118-121. (PMID: 29260667)
      Am J Hematol. 2018 Aug;93(4):590-594. (PMID: 29282755)
      Am J Trop Med Hyg. 2007 Dec;77(6):1157-62. (PMID: 18165540)
      Am J Trop Med Hyg. 2019 Feb;100(2):445-451. (PMID: 30526745)
      JAMA Neurol. 2018 Jun 1;75(6):746-750. (PMID: 29554185)
      Virol J. 2011 Mar 24;8:136. (PMID: 21435230)
      Epilepsia Open. 2018 Apr 17;3(2):286-289. (PMID: 29881809)
      Clin Transplant. 2010 Mar-Apr;24(2):223-8. (PMID: 19659514)
      Am J Trop Med Hyg. 2015 Aug;93(2):384-9. (PMID: 26033022)
      Clin Infect Dis. 1999 Jun;28(6):1294-7. (PMID: 10451169)
    • Grant Information:
      KL2 TR001100 United States TR NCATS NIH HHS; T32 AI007061 United States AI NIAID NIH HHS; R21 AI129455 United States AI NIAID NIH HHS; K08 NS096117 United States NS NINDS NIH HHS; U19 AI110818 United States AI NIAID NIH HHS
    • Contributed Indexing:
      Keywords: Jamestown Canyon virus; arbovirus; encephalitis; metagenomic next-generation sequencing; monoclonal antibody; orthobunyavirus; rituximab; vector-borne infections; viruses
    • Accession Number:
      0 (Antibodies, Viral)
      4F4X42SYQ6 (Rituximab)
    • Publication Date:
      Date Created: 20201202 Date Completed: 20210618 Latest Revision: 20230123
    • Publication Date:
      20230123
    • Accession Number:
      PMC7774567
    • Accession Number:
      10.3201/eid2701.203448
    • Accession Number:
      33261720