Remote testing of vitamin D levels across the UK MS population-A case control study.

Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE

Original Publication: San Francisco, CA : Public Library of Science

Dietary Supplements*; Multiple Sclerosis/*blood ; Vitamin D/*blood ; Vitamin D Deficiency/*blood; Adult ; Aged ; Case-Control Studies ; Cross-Sectional Studies ; Dried Blood Spot Testing ; Female ; Humans ; Male ; Middle Aged ; Multiple Sclerosis/complications ; Multiple Sclerosis/diagnosis ; Multiple Sclerosis/diet therapy ; Surveys and Questionnaires ; United Kingdom ; Vitamin D/administration & dosage ; Vitamin D Deficiency/complications ; Vitamin D Deficiency/diagnosis ; Vitamin D Deficiency/diet therapy

Objective: The association between vitamin D deficiency and multiple sclerosis (MS) is well described. We set out to use remote sampling to ascertain vitamin D status and vitamin D supplementation in a cross-sectional study of people with MS across the UK.
Methods: People with MS and matched controls were recruited from across the UK. 1768 people with MS enrolled in the study; remote sampling kits were distributed to a subgroup. Dried blood spots (DBS) were used to assess serum 25(OH)D in people with MS and controls.
Results: 1768 MS participants completed the questionnaire; 388 MS participants and 309 controls provided biological samples. Serum 25(OH)D was higher in MS than controls (median 71nmol/L vs 49nmol/L). A higher proportion of MS participants than controls supplemented (72% vs 26%, p<0.001); people with MS supplemented at higher vD doses than controls (median 1600 vs 600 IU/day, p<0.001). People with MS who did not supplement had lower serum 25(OH)D levels than non-supplementing controls (median 38 nmol/L vs 44 nmol/L). Participants engaged well with remote sampling.
Conclusions: The UK MS population have higher serum 25(OH)D than controls, mainly as a result of vitamin D supplementation. Remote sampling is a feasible way of carrying out large studies.
Competing Interests: None of the authors have any financial disclosures or competing interests relevant to this work.

J Neurol Sci. 2020 Apr 15;411:116668. (PMID: 32004798)
J Clin Endocrinol Metab. 2014 Sep;99(9):3319-24. (PMID: 24885629)
JAMA. 2001 Dec 26;286(24):3083-8. (PMID: 11754673)
Neurol Neuroimmunol Neuroinflamm. 2020 Jan 14;7(2):. (PMID: 31937597)
PLoS One. 2014 Aug 25;9(8):e104604. (PMID: 25153835)
Ann Epidemiol. 2009 Feb;19(2):73-8. (PMID: 18329892)
Cochrane Database Syst Rev. 2018 Sep 24;9:CD008422. (PMID: 30246874)
Mult Scler Relat Disord. 2018 Aug;24:3-10. (PMID: 29860199)
Neurology. 2019 Nov 12;93(20):e1906-e1916. (PMID: 31594857)
Neurol Neuroimmunol Neuroinflamm. 2019 Aug 6;6(5):. (PMID: 31454777)
Mult Scler Relat Disord. 2018 Oct;25:329-333. (PMID: 30195201)
Neurology. 2017 Jan 3;88(1):44-51. (PMID: 27903815)
J Neurol. 2013 Oct;260(10):2505-10. (PMID: 23807152)
Mult Scler. 2016 Jul;22(8):1021-6. (PMID: 26459151)
J Neurol. 2018 Dec;265(12):2893-2905. (PMID: 30284038)
Clin Chim Acta. 2009 May;403(1-2):145-51. (PMID: 19232332)
Clin Neurol Neurosurg. 2019 Dec;187:105564. (PMID: 31669929)
Neurosci Lett. 2014 Jun 6;570:108-13. (PMID: 24769422)
Mult Scler J Exp Transl Clin. 2020 Jan 24;6(1):2055217320903474. (PMID: 32047645)
Pract Neurol. 2018 Feb;18(1):35-42. (PMID: 28947637)
JAMA. 2006 Dec 20;296(23):2832-8. (PMID: 17179460)
Ann Clin Biochem. 2017 May;54(3):355-361. (PMID: 27422135)

1406-16-2 (Vitamin D)

Date Created: 20201230 Date Completed: 20210118 Latest Revision: 20210118

20240105

PMC7773187

10.1371/journal.pone.0241459

33378408