Green synthesis of silver nanoparticles from Eriobotrya japonica extract: a promising approach against cancer cells proliferation, inflammation, allergic disorders and phagocytosis induction.

Publisher: Taylor & Francis Country of Publication: England NLM ID: 101594777 Publication Model: Print Cited Medium: Internet ISSN: 2169-141X (Electronic) Linking ISSN: 21691401 NLM ISO Abbreviation: Artif Cells Nanomed Biotechnol Subsets: MEDLINE

Publication: 2015- : Abingdon, Oxford : Taylor & Francis
Original Publication: London : Informa Healthcare, [2013]-

Antineoplastic Agents*/chemical synthesis ; Antineoplastic Agents*/chemistry ; Green Chemistry Technology* ; Hypersensitivity*/drug therapy ; Hypersensitivity*/metabolism ; Hypersensitivity*/pathology ; Metal Nanoparticles*/chemistry ; Metal Nanoparticles*/therapeutic use ; Neoplasms*/drug therapy ; Neoplasms*/metabolism ; Neoplasms*/pathology ; Silver*/chemistry ; Silver*/pharmacology; Cell Proliferation/*drug effects ; Eriobotrya/*chemistry ; Plant Extracts/*chemistry; Animals ; HeLa Cells ; Humans ; Inflammation/drug therapy ; Inflammation/metabolism ; Inflammation/pathology ; MCF-7 Cells ; Male ; Mice ; Phagocytosis

Nanoparticles (NPs) have biological activities like antibacterial, antifungal, drug delivery, immunomodulation and antitumor activities. The aim of the current study was to investigate some of biomedical applications of silver NP synthesis using extracts from leaves of Eriobotrya japonica . Colour changes, UV-visible spectroscopy, SEM, zeta potential, dynamic light scattering, FTIR and XRD were used to confirm AgNPs formation. The UV-vis spectrum absorption band was observed at almost 430 nm. The SEM image shows quasi-spherical shape of AgNPs. The zeta potential demonstrated the negative surface charge of NPs. FTIR results showed the functional groups of AgNPs. Crystalline nature of AgNPs was confirmed by XRD pattern. MTT assay was used to study the anti-proliferative activity against MCF-7 and HeLa cells. Apoptosis was tested using a DNA-fragmentation test, and expression of P ⁵³ . AgNPs inhibited the proliferation of MCF-7 and HeLa cells, and reduced inflammation. Treatment with AgNPs significantly decreased allergic disorder. AgNPs stimulated the phagocytosis process in BMDMs. The results suggested that AgNPs could be a promising therapy for future and preventing inflammation, reduce allergic disorders and prevent bacterial infection through the up-regulation of phagocytosis. Hence, future work such as developed and improved NPs as adjuvants, immune-modulating substances and nano-drug delivery system is needed.

Keywords: Eriobotrya japonica; allergy; anticancer; apoptosis; phagocytosis; silver nanoparticles

0 (Antineoplastic Agents)
0 (Plant Extracts)
3M4G523W1G (Silver)

Date Created: 20210106 Date Completed: 20210902 Latest Revision: 20210902

20240105

10.1080/21691401.2020.1867152

33403879