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Clinico-pathological associations of serum VCAM-1 and ICAM-1 levels in patients with lupus nephritis.
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- Author(s): Yu KY;Yu KY; Yung S; Yung S; Chau MK; Chau MK; Tang CS; Tang CS; Yap DY; Yap DY; Tang AH; Tang AH; Ying SK; Ying SK; Lee CK; Lee CK; Chan TM; Chan TM
- Source:
Lupus [Lupus] 2021 Jun; Vol. 30 (7), pp. 1039-1050. Date of Electronic Publication: 2021 Mar 26.- Publication Type:
Journal Article- Language:
English - Source:
- Additional Information
- Source: Publisher: SAGE Publications Country of Publication: England NLM ID: 9204265 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1477-0962 (Electronic) Linking ISSN: 09612033 NLM ISO Abbreviation: Lupus Subsets: MEDLINE
- Publication Information: Publication: London : SAGE Publications
Original Publication: Houndmills, Basingstoke, Hampshire, UK : Scientific & Medical Division, Macmillan Press Ltd., c1991- - Subject Terms: Intercellular Adhesion Molecule-1/*blood ; Lupus Nephritis/*metabolism ; Lupus Nephritis/*pathology ; Vascular Cell Adhesion Molecule-1/*blood; Adult ; Antibodies, Antinuclear/blood ; Biomarkers/blood ; Biopsy ; Case-Control Studies ; Complement C3/metabolism ; Creatinine/blood ; Early Diagnosis ; Enzyme-Linked Immunosorbent Assay/methods ; Female ; Humans ; Hyaluronic Acid/blood ; Kidney/pathology ; Lupus Nephritis/classification ; Lupus Nephritis/diagnosis ; Male ; Middle Aged ; Proteinuria/complications ; Proteinuria/diagnosis ; ROC Curve ; Syndecan-1/blood ; Thrombomodulin/blood
- Abstract: Objective: We investigated the clinico-pathological associations of serum VCAM-1 and ICAM-1 levels in patients with biopsy-proven Class III/IV±V lupus nephritis (LN).
Methods: Serum VCAM-1 and ICAM-1 levels were determined by ELISAs. Sera from patients with non-renal SLE or non-lupus chronic kidney disease (CKD), and healthy subjects served as controls.
Results: Seropositivity rate for VCAM-1 and ICAM-1 was 93.10% and 37.93% respectively at the time of nephritic flare, and 44.83% and 13.79% respectively at remission, with both showing higher levels during flare ( P < 0.05, for both). VCAM-1 level correlated with proteinuria, serum creatinine, and anti-dsDNA antibodies, and inversely correlated with C3. VCAM-1 level also correlated with leukocyte infiltration and fibrinoid necrosis/karyorrhexis scores in active LN kidney biopsies. ICAM-1 level correlated with proteinuria, but not anti-dsDNA or C3, nor histopathological features. VCAM-1 level increased 4.5 months before renal flare, while ICAM-1 increase coincided with flare, and both decreased after treatment. ROC analysis showed that VCAM-1 distinguished active LN from healthy subjects, LN in remission, active non-renal lupus, and CKD (ROC AUC of 0.98, 0.86, 0.93 and 0.90 respectively). VCAM-1 level in combination with either proteinuria or C3 was superior in distinguishing active LN from remission compared to the measurement of individual markers. Serum ICAM-1 level distinguished active LN from healthy subjects and LN patients in remission (ROC AUC of 0.75 and 0.66 respectively), but did not distinguish between renal versus non-renal lupus. ICAM-1 level in combination with markers of endothelial cell activation (syndecan-1, hyaluronan and thrombomodulin) was superior to proteinuria, anti-dsDNA, or C3 in distinguishing active LN from quiescent disease.
Conclusion: Our findings suggest potential utility of serum VCAM-1 and ICAM-1 in clinical management. Monitoring VCAM-1 may facilitate early diagnosis of flare. Combining selected biomarkers may be advantageous in diagnosing active LN. VCAM-1 may have a pathogenic role in renal parenchymal inflammation in active LN. - Contributed Indexing: Keywords: Lupus nephritis; Vascular cell adhesion molecule-1, Intercellular adhesion molecule-1
- Accession Number: 0 (Antibodies, Antinuclear)
0 (Biomarkers)
0 (C3 protein, human)
0 (Complement C3)
0 (SDC1 protein, human)
0 (Syndecan-1)
0 (Thrombomodulin)
0 (Vascular Cell Adhesion Molecule-1)
0 (anti-dsDNA autoantibody)
126547-89-5 (Intercellular Adhesion Molecule-1)
9004-61-9 (Hyaluronic Acid)
AYI8EX34EU (Creatinine) - Publication Date: Date Created: 20210326 Date Completed: 20211103 Latest Revision: 20211103
- Publication Date: 20240105
- Accession Number: 10.1177/09612033211004727
- Accession Number: 33765901
- Source:
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