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Environmental toxicants, oxidative stress and health adversities: interventions of phytochemicals.
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- Author(s): Dwivedi S;Dwivedi S; Kushalan S; Kushalan S; Paithankar JG; Paithankar JG; D'Souza LC; D'Souza LC; Hegde S; Hegde S; Sharma A; Sharma A
- Source:
The Journal of pharmacy and pharmacology [J Pharm Pharmacol] 2022 Apr 20; Vol. 74 (4), pp. 516-536.- Publication Type:
Journal Article; Review- Language:
English - Source:
- Additional Information
- Source: Publisher: Oxford University Press Country of Publication: England NLM ID: 0376363 Publication Model: Print Cited Medium: Internet ISSN: 2042-7158 (Electronic) Linking ISSN: 00223573 NLM ISO Abbreviation: J Pharm Pharmacol Subsets: MEDLINE
- Publication Information: Publication: 2021- : [Oxford] : Oxford University Press
Original Publication: London : Pharmaceutical Society of Great Britain - Subject Terms:
- Abstract: Objectives: Oxidative stress is the most common factor mediating environmental chemical-induced health adversities. Recently, an exponential rise in the use of phytochemicals as an alternative therapeutics against oxidative stress-mediated diseases has been documented. Due to their free radical quenching property, plant-derived natural products have gained substantial attention as a therapeutic agent in environmental toxicology. The present review aimed to describe the therapeutic role of phytochemicals in mitigating environmental toxicant-mediated sub-cellular and organ toxicities via controlling cellular antioxidant response.
Methods: The present review has covered the recently related studies, mainly focussing on the free radical scavenging role of phytochemicals in environmental toxicology.
Key Findings: In vitro and in vivo studies have reported that supplementation of antioxidant-rich compounds can ameliorate the toxicant-induced oxidative stress, thereby improving the health conditions. Improving the cellular antioxidant pool has been considered as a mode of action of phytochemicals. However, the other cellular targets of phytochemicals remain uncertain.
Conclusions: Knowing the therapeutic value of phytochemicals to mitigate the chemical-induced toxicity is an initial stage; mechanistic understanding needs to decipher for development as therapeutics. Moreover, examining the efficacy of phytochemicals against mixer toxicity and identifying the bioactive molecule are major challenges in the field.
(© The Author(s) 2021. Published by Oxford University Press on behalf of the Royal Pharmaceutical Society. All rights reserved. For permissions, please e-mail: [email protected].) - Grant Information: ECR/2016/001863 Science and Engineering Research Board; NU/DR/NUFR1/NUCSER/2019-20/01 Nitte Research Grant; SRF 2020-8275/CMB-BMS Indian Council of Medical Research; 09/1257(0001)/2019-EMR-I Council of Scientific and Industrial Research, India
- Contributed Indexing: Keywords: environmental chemicals; oxidative stress; phytochemicals; therapeutics
- Accession Number: 0 (Antioxidants)
0 (Phytochemicals) - Publication Date: Date Created: 20210406 Date Completed: 20220422 Latest Revision: 20220422
- Publication Date: 20240104
- Accession Number: 10.1093/jpp/rgab044
- Accession Number: 33822130
- Source:
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