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Association of antiphospholipid antibodies with clinical activity and renal pathological activity in patients with lupus nephritis.
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- Author(s): Zhang J;Zhang J; Zhang J; Zhang J; Zhou Q; Zhou Q; Lu G; Lu G; You X; You X
- Source:
Lupus [Lupus] 2021 Jun; Vol. 30 (7), pp. 1140-1145. Date of Electronic Publication: 2021 Apr 08.- Publication Type:
Journal Article- Language:
English - Source:
- Additional Information
- Source: Publisher: SAGE Publications Country of Publication: England NLM ID: 9204265 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1477-0962 (Electronic) Linking ISSN: 09612033 NLM ISO Abbreviation: Lupus Subsets: MEDLINE
- Publication Information: Publication: London : SAGE Publications
Original Publication: Houndmills, Basingstoke, Hampshire, UK : Scientific & Medical Division, Macmillan Press Ltd., c1991- - Subject Terms: Antibodies, Anticardiolipin/*blood ; Antibodies, Antiphospholipid/*blood ; Kidney/*pathology ; Lupus Coagulation Inhibitor/*blood ; Lupus Nephritis/*immunology; Adult ; Antiphospholipid Syndrome/complications ; Antiphospholipid Syndrome/diagnosis ; Antiphospholipid Syndrome/immunology ; Biopsy ; Case-Control Studies ; China/epidemiology ; Complement Activation/immunology ; Female ; Hematuria/epidemiology ; Hematuria/etiology ; Humans ; Immunoglobulin G/blood ; Kidney Glomerulus/immunology ; Kidney Glomerulus/pathology ; Lupus Nephritis/pathology ; Lupus Nephritis/physiopathology ; Male ; Middle Aged ; Retrospective Studies ; Severity of Illness Index ; Thrombotic Microangiopathies/epidemiology ; Thrombotic Microangiopathies/etiology
- Abstract: Objectives: This study aimed to investigate the association of antiphospholipid antibodies (aPL) with clinical activity and renal pathological activity in patients with lupus nephritis (LN).
Methods: Levels of anticardiolipin () antibodies, anti-β2-glycoprotein I (anti-β2-GPI) antibodies and lupus anticoagulant (LAC) were measured, and other clinical and pathological data were also obtained during the same period before renal biopsy.
Results: A total of 83 patients with LN were included in this study, 40 patients (48.2%) in the s positive group and 43 patients in the aPL negative group. LN patients with positive aPL had significantly higher SLEDAI (p = 0.012), more hematuria (p = 0.043), lower serum C3 (p = 0.003) and C4 (p = 0.014), and a higher pathological activity index (p = 0.012), more micro-thrombosis (p = 0.046) and more C3 deposits (p = 0.038) in the glomerulus than patients with negative aPL The level of IgG- was significantly correlated with SLEDAI and serum level of C3 (r = 0.44, p < 0.001; r = -0.39, p = 0.003, respectively). The level of IgM- was significantly correlated with SLEDAI, and serum levels of C3 and C4 (r = 0.27, p = 0.014; r = -0.22, p = 0.041; r = -0.23, p = 0.035, respectively).
Conclusions: Our work suggests that aPL, especially, are correlated with both clinical activity and renal pathological activity in patients with LN. - Contributed Indexing: Keywords: Lupus nephritis (LN); anticardiolipin antibodies; antiphospholipid antibodies (aPL); disease activity
- Accession Number: 0 (Antibodies, Anticardiolipin)
0 (Antibodies, Antiphospholipid)
0 (Immunoglobulin G)
0 (Lupus Coagulation Inhibitor)
0 (anti-beta 2 glycoprotein I autoantibody) - Publication Date: Date Created: 20210409 Date Completed: 20211103 Latest Revision: 20211103
- Publication Date: 20240104
- Accession Number: 10.1177/09612033211006781
- Accession Number: 33832360
- Source:
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