Field infection of a gilt and its litter demonstrates vertical transmission and effect on reproductive failure caused by porcine circovirus type 3 (PCV3).

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  • Additional Information
    • Source:
      Publisher: BioMed Central Country of Publication: England NLM ID: 101249759 Publication Model: Electronic Cited Medium: Internet ISSN: 1746-6148 (Electronic) Linking ISSN: 17466148 NLM ISO Abbreviation: BMC Vet Res Subsets: MEDLINE
    • Publication Information:
      Original Publication: London : BioMed Central, 2005-
    • Subject Terms:
    • Abstract:
      Background: PCV3 is a member of the Circovirus family, associated with disease and mortality in pigs. It is not clear whether PCV3 putatively causes clinical symptoms and disease. In the present case, we reported a gilt infected with PCV3 associated with reproductive failures, vertical transmission, tissue lesions, viral replication by in situ hybridization, and the hypothesis that some strains of PCV3 clade one are associated with reproductive failures at the field level.
      Case Presentation: In May 2019, a pig farm in Colombia reported increased reproductive failures, and the presence of PCV3 in gilts and sows was established in a single form or coinfections, mainly with PCV2 and PPV7. Ten sows with a single infection with PCV3 were found, and one gilt with a pre-farrowing serum viral load above 10 3 was studied. This gilt was followed up during the pre-farrowing, farrowing period and on her litter for 6 weeks. During dystocic farrowing, a mummy and ten piglets were released, including two weak-born piglets. The highest viral loads for PCV3 were found in the mummy and the placenta. In the weak-born piglets, there were viral loads both in serum and in tissues, mainly in the mesenteric ganglia and lung. Replication of PCV3 in these tissues was demonstrated by in situ hybridizations. PCV3 was also found in the precolostrum sera of piglets and colostrum, showing vertical transmission. The viral load in piglets decreased gradually until week six of life. The viral genome's complete sequencing was made from the mummy, and its analysis classified it as PCV3 clade one.
      Conclusions: This report confirms that PCV3 can cause disease at the field level, and putatively, in this case, we find the generation of reproductive failures. The ability of PCV3 to cause disease as a putative pathogen may be associated with the viral load present in the pig and the strain that is affecting the farm. For this case, we found that viral loads above 10 3 (4.93 log genomic copies / mL) in the gilt were associated with clinical manifestation and that some PCV3 strains belonging to clade one are more associated with the reproductive presentation.
    • References:
      Can J Vet Res. 2009 Oct;73(4):308-12. (PMID: 20046634)
      J Vet Med Sci. 2018 Sep 26;80(9):1468-1472. (PMID: 30078831)
      Vet Med Sci. 2019 May;5(2):182-188. (PMID: 30741489)
      BMC Vet Res. 2018 Sep 26;14(1):294. (PMID: 30257676)
      Vet Microbiol. 2018 Jul;220:12-17. (PMID: 29885795)
      Microb Pathog. 2020 Apr;141:104027. (PMID: 32007620)
      Infect Genet Evol. 2019 Mar;68:127-135. (PMID: 30572028)
      Vet Microbiol. 2017 Aug;207:178-180. (PMID: 28757021)
      Arch Virol. 2018 Oct;163(10):2841-2847. (PMID: 29948384)
      Transbound Emerg Dis. 2018 Oct;65(5):1290-1296. (PMID: 29654637)
      Transbound Emerg Dis. 2017 Oct;64(5):1350-1353. (PMID: 28649803)
      Transbound Emerg Dis. 2020 May;67(3):1057-1061. (PMID: 31823481)
      Vet Microbiol. 2020 Feb;241:108576. (PMID: 31928694)
      Transbound Emerg Dis. 2017 Dec;64(6):1650-1654. (PMID: 28975769)
      Viruses. 2020 Feb 16;12(2):. (PMID: 32079070)
      Viruses. 2019 Feb 21;11(2):. (PMID: 30795620)
      Transbound Emerg Dis. 2017 Oct;64(5):1337-1341. (PMID: 28653486)
      J Gen Virol. 2017 Aug;98(8):1997-1998. (PMID: 28786778)
      Viruses. 2020 Feb 28;12(3):. (PMID: 32121102)
      Mol Phylogenet Evol. 2019 Oct;139:106520. (PMID: 31152778)
      Infect Genet Evol. 2019 Sep;73:227-233. (PMID: 31096019)
      Emerg Microbes Infect. 2019;8(1):684-698. (PMID: 31096848)
      Transbound Emerg Dis. 2018 Feb;65(1):5-9. (PMID: 29027372)
      Transbound Emerg Dis. 2020 May;67(3):1284-1294. (PMID: 31886622)
      Arch Virol. 2019 Oct;164(10):2435-2449. (PMID: 31273470)
      Front Vet Sci. 2018 Dec 12;5:315. (PMID: 30631769)
      Transbound Emerg Dis. 2018 Oct;65(5):1163-1169. (PMID: 29877052)
      BMC Vet Res. 2018 Oct 26;14(1):321. (PMID: 30367641)
      Virol J. 2016 Nov 11;13(1):184. (PMID: 27835942)
      Transbound Emerg Dis. 2020 May;67(3):1062-1067. (PMID: 31880100)
      Vet Microbiol. 2018 Feb;215:71-76. (PMID: 29426409)
      BMC Vet Res. 2019 Jul 15;15(1):244. (PMID: 31307451)
      Transbound Emerg Dis. 2018 Jun;65(3):602-606. (PMID: 29453822)
      Vet Rec. 2019 Jul 20;185(3):84. (PMID: 31177090)
      BMC Vet Res. 2019 Jun 13;15(1):200. (PMID: 31196107)
      Transbound Emerg Dis. 2018 Apr;65(2):e296-e303. (PMID: 29178283)
      PLoS One. 2018 Jun 29;13(6):e0199950. (PMID: 29958294)
      Front Vet Sci. 2019 Nov 15;6:403. (PMID: 31803766)
      Genome Announc. 2018 Apr 26;6(17):. (PMID: 29700145)
      J Vet Sci. 2018 Sep 30;19(5):721-724. (PMID: 30041289)
      Mol Biol Evol. 2016 Jul;33(7):1870-4. (PMID: 27004904)
      J Virol. 2019 Feb 5;93(4):. (PMID: 30487279)
      Transbound Emerg Dis. 2019 Jan;66(1):91-101. (PMID: 30091190)
      J Virol. 2016 Dec 16;91(1):. (PMID: 27795441)
    • Contributed Indexing:
      Keywords: PCV3; Porcine circovirus 3; Putative infection; Reproductive failure; Viral load
    • Publication Date:
      Date Created: 20210409 Date Completed: 20210824 Latest Revision: 20210824
    • Publication Date:
      20210914
    • Accession Number:
      PMC8028087
    • Accession Number:
      10.1186/s12917-021-02862-5
    • Accession Number:
      33832500