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Epidemiology, clinical characteristics, and treatment outcomes of patients with COVID-19 at Thailand's university-based referral hospital.
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- Author(s): Sirijatuphat R;Sirijatuphat R; Suputtamongkol Y; Suputtamongkol Y; Angkasekwinai N; Angkasekwinai N; Horthongkham N; Horthongkham N; Chayakulkeeree M; Chayakulkeeree M; Rattanaumpawan P; Rattanaumpawan P; Koomanachai P; Koomanachai P; Assanasen S; Assanasen S; Rongrungruang Y; Rongrungruang Y; Chierakul N; Chierakul N; Ratanarat R; Ratanarat R; Jitmuang A; Jitmuang A; Wangchinda W; Wangchinda W; Kantakamalakul W; Kantakamalakul W
- Source:
BMC infectious diseases [BMC Infect Dis] 2021 Apr 26; Vol. 21 (1), pp. 382. Date of Electronic Publication: 2021 Apr 26.- Publication Type:
Journal Article- Language:
English - Source:
- Additional Information
- Source: Publisher: BioMed Central Country of Publication: England NLM ID: 100968551 Publication Model: Electronic Cited Medium: Internet ISSN: 1471-2334 (Electronic) Linking ISSN: 14712334 NLM ISO Abbreviation: BMC Infect Dis Subsets: MEDLINE
- Publication Information: Original Publication: London : BioMed Central, [2001-
- Subject Terms: COVID-19/*epidemiology; Adult ; Aged ; Aged, 80 and over ; Amides/therapeutic use ; Antiviral Agents/therapeutic use ; Chloroquine/therapeutic use ; Darunavir/therapeutic use ; Disease Progression ; Drug Combinations ; Female ; Hospitals ; Hospitals, University ; Humans ; Hydroxychloroquine/therapeutic use ; Lopinavir/therapeutic use ; Male ; Middle Aged ; Pyrazines/therapeutic use ; Referral and Consultation ; Retrospective Studies ; Ritonavir/therapeutic use ; Thailand/epidemiology ; Treatment Outcome ; Young Adult ; COVID-19 Drug Treatment
- Abstract: Background: The epidemiology and outcomes of COVID-19 patients in Thailand are scarce.
Methods: This retrospective cohort study included adult hospitalized patients who were diagnosed with COVID-19 at Siriraj Hospital during February 2020 to April 2020.
Results: The prevalence of COVID-19 was 7.5% (107 COVID-19 patients) among 1409 patients who underwent RT-PCR for SARS-CoV-2 detection at our hospital during the outbreak period. Patients with COVID-19 presented with symptoms in 94.4%. Among the 104 patients who were treated with antiviral medications, 78 (75%) received 2-drug regimen (lopinavir/ritonavir or darunavir/ritonavir plus chloroquine or hydroxychloroquine), and 26 (25%) received a 3-drug regimen with favipiravir added to the 2-drug regimen. Disease progression was observed in 18 patients (16.8%). All patients with COVID-19 were discharged alive.
Conclusions: The prevalence of COVID-19 was 7.5% among patients who underwent RT-PCR testing, and 10% among those having risk factors for COVID-19 acquisition. Combination antiviral therapies for COVID-19 patients were well-tolerated and produced a favorable outcome. - References: JAMA. 2020 Apr 7;323(13):1239-1242. (PMID: 32091533)
Infection. 2020 Oct;48(5):687-694. (PMID: 32390091)
Euro Surveill. 2020 Feb;25(8):. (PMID: 32127124)
Emerg Infect Dis. 2020 Jul;26(7):. (PMID: 32364890)
N Engl J Med. 2020 Apr 30;382(18):1708-1720. (PMID: 32109013)
Clin Infect Dis. 2020 Apr 27;:. (PMID: 32338708)
Emerg Infect Dis. 2020 Jul;26(7):1580-1585. (PMID: 32267826)
N Engl J Med. 2020 Mar 12;382(11):1067-1068. (PMID: 32050060)
J Intern Med. 2020 Aug;288(2):192-206. (PMID: 32348588)
Am J Trop Med Hyg. 2020 May;102(5):940-942. (PMID: 32238223)
JAMA. 2020 May 19;323(19):1966-1967. (PMID: 32232421)
Clin Chem Lab Med. 2020 Jun 25;58(7):1021-1028. (PMID: 32286245)
JAMA. 2020 Jun 9;323(22):2249-2251. (PMID: 32374370)
JAMA Cardiol. 2020 Sep 1;5(9):1036-1041. (PMID: 32936252)
Clin Microbiol Infect. 2020 Jul;26(7):842-847. (PMID: 32344166) - Contributed Indexing: Keywords: COVID-19; Clinical characteristics; Epidemiology; Outcome; Thailand; Treatment
- Accession Number: 0 (Amides)
0 (Antiviral Agents)
0 (Drug Combinations)
0 (Pyrazines)
0 (lopinavir-ritonavir drug combination)
2494G1JF75 (Lopinavir)
4QWG6N8QKH (Hydroxychloroquine)
886U3H6UFF (Chloroquine)
EW5GL2X7E0 (favipiravir)
O3J8G9O825 (Ritonavir)
YO603Y8113 (Darunavir) - Publication Date: Date Created: 20210427 Date Completed: 20210428 Latest Revision: 20221207
- Publication Date: 20240105
- Accession Number: PMC8072093
- Accession Number: 10.1186/s12879-021-06081-z
- Accession Number: 33902480
- Source:
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