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Circular RNA circSMARCA5 is a prognostic biomarker in patients with malignant tumor: a meta-analysis.
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- Author(s): Chao F;Chao F; Wang S; Wang S; Zhang C; Zhang C; Han D; Han D; Ma Z; Ma Z; Chen G; Chen G
- Source:
BMC cancer [BMC Cancer] 2021 May 25; Vol. 21 (1), pp. 600. Date of Electronic Publication: 2021 May 25.- Publication Type:
Journal Article; Meta-Analysis; Systematic Review- Language:
English - Source:
- Additional Information
- Source: Publisher: BioMed Central Country of Publication: England NLM ID: 100967800 Publication Model: Electronic Cited Medium: Internet ISSN: 1471-2407 (Electronic) Linking ISSN: 14712407 NLM ISO Abbreviation: BMC Cancer Subsets: MEDLINE
- Publication Information: Original Publication: London : BioMed Central, [2001-
- Subject Terms: Gene Expression Regulation, Neoplastic*; Biomarkers, Tumor/*metabolism ; Neoplasms/*mortality ; RNA, Circular/*metabolism; Biomarkers, Tumor/analysis ; Carcinogenesis/genetics ; Cell Differentiation/genetics ; Humans ; Lymphatic Metastasis/genetics ; Neoplasms/genetics ; Neoplasms/pathology ; Neoplasms/therapy ; Prognosis ; RNA, Circular/analysis
- Abstract: Background: Malignant tumor is one of the most serious diseases endangering human health. Circular RNAs play an important role in the tumorigenesis and progression of various malignant tumors. Although various studies have investigated the biological function of circular RNA circSMARCA5 in malignant tumors, the prognostic value of circSMARCA5 in malignant tumor patients has not been systematically analyzed.
Methods: Relevant studies were obtained from the PubMed and Web of Science database. The quality of the enrolled studies was evaluated using the Newcastle-Ottawa Scale quality assessment system. Survival features and clinicopathological features were assessed using pooled hazard ratios and odds ratios with 95% confidence intervals, respectively.
Results: Overall, 7 relevant publications were enrolled in the meta-analysis. CircSMARCA5 expression was significantly correlated with better OS (HR = 0.51, 95%CI 0.41-0.65) or DFS/RFS/PFS (HR = 0.56, 95%CI 0.43-0.73) in malignant tumors. In the pooled analyses of clinicopathological characteristics, malignant tumors with higher circSMARCA5 were better differentiated (OR = 0.41, 95%CI 0.19-0.88). CircSMARCA5 expression was correlated with less advanced TNM stage (OR = 0.33, 95%CI 0.19-0.55). Moreover, malignant tumors with higher circSMARCA5 expression have less advanced lymph node metastasis (OR = 0.26, 95%CI 0.08-0.79).
Conclusion: These results indicated that circSMARCA5 was a promising biomarker in malignant tumors, which may potentially facilitate clinical decisions in the future. - References: RNA. 2014 Nov;20(11):1666-70. (PMID: 25234927)
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Cancer Gene Ther. 2021 Jan 29;:. (PMID: 33514881) - Grant Information: 18ZR1405800 National Science Foundation of Shanghai; JSZK2019A03 Project for Key Medical Specialty Construction in Jinshan District (6th Period, Type A)
- Contributed Indexing: Keywords: Biomarker; Circular RNA; Malignant tumor; circSMARCA5
- Accession Number: 0 (Biomarkers, Tumor)
0 (RNA, Circular) - Publication Date: Date Created: 20210526 Date Completed: 20211018 Latest Revision: 20211018
- Publication Date: 20240105
- Accession Number: PMC8145840
- Accession Number: 10.1186/s12885-021-08316-3
- Accession Number: 34034688
- Source:
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