La Crosse Virus Disease in the United States, 2003-2019.

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  • Additional Information
    • Source:
      Publisher: American Society of Tropical Medicine and Hygiene Country of Publication: United States NLM ID: 0370507 Publication Model: Electronic Cited Medium: Internet ISSN: 1476-1645 (Electronic) Linking ISSN: 00029637 NLM ISO Abbreviation: Am J Trop Med Hyg Subsets: MEDLINE
    • Publication Information:
      Publication: Northbrook, IL : American Society of Tropical Medicine and Hygiene
      Original Publication: Baltimore.
    • Subject Terms:
    • Abstract:
      La Crosse virus (LACV) is an arthropod-borne virus that can cause a nonspecific febrile illness, meningitis, or encephalitis. We reviewed U.S. LACV surveillance data for 2003-2019, including human disease cases and nonhuman infections. Overall, 318 counties in 27 states, principally in the Great Lakes, mid-Atlantic, and southeastern regions, reported LACV activity. A total of 1,281 human LACV disease cases were reported, including 1,183 (92%) neuroinvasive disease cases. The median age of cases was 8 years (range: 1 month-95 years); 1,130 (88%) were aged < 18 years, and 754 (59%) were male. The most common clinical syndromes were encephalitis (N = 960; 75%) and meningitis (N = 219, 17%). The case fatality rate was 1% (N = 15). A median of 74 cases (range: 35-130) was reported per year. The average annual national incidence of neuroinvasive disease cases was 0.02 per 100,000 persons. West Virginia, North Carolina, Tennessee, and Ohio had the highest average annual state incidences (0.16-0.61 per 100,000), accounting for 80% (N = 1,030) of cases. No animal LACV infections were reported. Nine states reported LACV-positive mosquito pools, including three states with no reported human disease cases. La Crosse virus is the most common cause of pediatric neuroinvasive arboviral disease in the United States. However, surveillance data likely underestimate LACV disease incidence. Healthcare providers should consider LACV disease in patients, especially children, with febrile illness, meningitis, or encephalitis in areas where the virus circulates and advise their patients on ways to prevent mosquito bites.
    • References:
      MMWR Morb Mortal Wkly Rep. 2018 Oct 05;67(39):1104-1105. (PMID: 30286057)
      Epidemiol Infect. 2018 Dec 05;147:e66. (PMID: 30516125)
      Emerg Infect Dis. 2015 May;21(5):833-6. (PMID: 25898269)
      J Virol. 2014 Oct;88(19):11070-9. (PMID: 25008929)
      Am J Trop Med Hyg. 2008 Dec;79(6):974-9. (PMID: 19052314)
      Virology. 2017 Dec;512:201-210. (PMID: 28985574)
      Infect Dis Clin North Am. 1991 Mar;5(1):73-102. (PMID: 1646839)
      Am J Epidemiol. 1965 Mar;81:245-53. (PMID: 14261030)
      Am J Epidemiol. 1984 Jun;119(6):913-30. (PMID: 6328975)
      Virus Res. 1997 May;48(2):143-8. (PMID: 9175252)
      Pediatr Infect Dis J. 2019 Jan;38(1):37-41. (PMID: 30531527)
      Prog Clin Biol Res. 1983;123:31-41. (PMID: 6867038)
      Am J Trop Med Hyg. 2015 Aug;93(2):384-9. (PMID: 26033022)
      Emerg Infect Dis. 2005 Aug;11(8):1167-73. (PMID: 16102302)
      J Neuroinflammation. 2017 Mar 24;14(1):62. (PMID: 28340587)
      Pediatrics. 2014 Sep;134(3):e642-50. (PMID: 25113294)
      Clin Microbiol Rev. 1994 Jan;7(1):89-116. (PMID: 8118792)
      Am J Epidemiol. 2002 Jun 1;155(11):1060-5. (PMID: 12034585)
    • Publication Date:
      Date Created: 20210719 Date Completed: 20211011 Latest Revision: 20220902
    • Publication Date:
      20240105
    • Accession Number:
      PMC8592351
    • Accession Number:
      10.4269/ajtmh.21-0294
    • Accession Number:
      34280142