Prognostic role of DFNA5 in head and neck squamous cell carcinoma revealed by systematic expression analysis.

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  • Additional Information
    • Source:
      Publisher: BioMed Central Country of Publication: England NLM ID: 100967800 Publication Model: Electronic Cited Medium: Internet ISSN: 1471-2407 (Electronic) Linking ISSN: 14712407 NLM ISO Abbreviation: BMC Cancer Subsets: MEDLINE
    • Publication Information:
      Original Publication: London : BioMed Central, [2001-
    • Subject Terms:
      Gene Expression Regulation, Neoplastic* ; Gene Regulatory Networks*; Biomarkers, Tumor/*metabolism ; Head and Neck Neoplasms/*pathology ; Receptors, Estrogen/*metabolism ; Squamous Cell Carcinoma of Head and Neck/*pathology; Biomarkers, Tumor/genetics ; Cell Adhesion ; Cell Proliferation ; Female ; Follow-Up Studies ; Head and Neck Neoplasms/genetics ; Head and Neck Neoplasms/metabolism ; Humans ; Male ; Prognosis ; Receptors, Estrogen/genetics ; Squamous Cell Carcinoma of Head and Neck/genetics ; Squamous Cell Carcinoma of Head and Neck/metabolism ; Survival Rate ; Tumor Cells, Cultured
    • Abstract:
      Background: The gasdermin E gene (GSDME, also known as DFNA5) is mutated in familial aging-related hearing loss. Recent studies have also revealed that the expression of DFNA5 is suppressed in many cancer types; however, little is known about the function of DFNA5 in head and neck squamous cell carcinoma (HNSCC). Accordingly, the aim of the present study was to evaluate the expression of DFNA5 and explore its prognostic value in HNSCC.
      Result: We used a set of bioinformatics tools, including Oncomine, TIMER, TISIDB, cBioPortal, and GEPIA, to analyze the expression of DFNA5 in patients with HNSCC from public databases. Kaplan-Meier plotter was used to evaluate the potential prognostic significance of DFNA5. DFNA5 mRNA levels were significantly higher in HNSCC tissues than in normal tissues, and high DFNA5 expression was correlated with worse survival. Gene Ontology and Kyoto Encyclopedia of Genes and Genomes pathway analyses showed that DFNA5 expression has a strong positive correlation with cell adhesion and the integrin signaling pathway, whereas its expression was negatively correlated with the levels of infiltrating B cells (cor = - 0.223, P = 8.57e-07) and CD8 T cells (cor = - 0.223, P = 2.99e-07).
      Conclusion: This study demonstrates that DFNA5 expression has prognostic value for HNSCC patients. Moreover, these results suggest that regulation of lymphocyte infiltration is the mechanism underlying the function of DFNA5 in HNSCC.
      (© 2021. The Author(s).)
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    • Contributed Indexing:
      Keywords: DFNA5; Head and neck cancer; Lymphocyte infiltration; Survival prognosis
    • Accession Number:
      0 (Biomarkers, Tumor)
      0 (GSDME protein, human)
      0 (Receptors, Estrogen)
    • Publication Date:
      Date Created: 20210826 Date Completed: 20211018 Latest Revision: 20211018
    • Publication Date:
      20240104
    • Accession Number:
      PMC8390204
    • Accession Number:
      10.1186/s12885-021-08692-w
    • Accession Number:
      34433433