Bioengineered phytomolecules-capped silver nanoparticles using Carissa carandas leaf extract to embed on to urinary catheter to combat UTI pathogens.

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  • Additional Information
    • Source:
      Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE
    • Publication Information:
      Original Publication: San Francisco, CA : Public Library of Science
    • Subject Terms:
      Anti-Bacterial Agents/*pharmacology ; Apocynaceae/*chemistry ; Biofilms/*drug effects ; Escherichia coli/*drug effects ; Phytochemicals/*pharmacology ; Pseudomonas aeruginosa/*drug effects ; Staphylococcus aureus/*drug effects; Anti-Bacterial Agents/chemical synthesis ; Biofilms/growth & development ; Ciprofloxacin/pharmacology ; Escherichia coli/growth & development ; Escherichia coli/pathogenicity ; Escherichia coli Infections/drug therapy ; Escherichia coli Infections/microbiology ; Gentamicins/pharmacology ; Green Chemistry Technology ; Humans ; Metal Nanoparticles/chemistry ; Metal Nanoparticles/ultrastructure ; Microbial Sensitivity Tests ; Particle Size ; Phytochemicals/chemistry ; Plant Extracts/chemistry ; Plant Leaves/chemistry ; Pseudomonas Infections/drug therapy ; Pseudomonas Infections/microbiology ; Pseudomonas aeruginosa/growth & development ; Pseudomonas aeruginosa/pathogenicity ; Silver/chemistry ; Silver/pharmacology ; Staphylococcal Infections/drug therapy ; Staphylococcal Infections/microbiology ; Staphylococcus aureus/growth & development ; Staphylococcus aureus/pathogenicity ; Trimethoprim/pharmacology ; Urinary Catheters/microbiology ; Urinary Tract Infections
    • Abstract:
      Rising incidents of urinary tract infections (UTIs) among catheterized patients is a noteworthy problem in clinic due to their colonization of uropathogens on abiotic surfaces. Herein, we have examined the surface modification of urinary catheter by embedding with eco-friendly synthesized phytomolecules-capped silver nanoparticles (AgNPs) to prevent the invasion and colonization of uropathogens. The preliminary confirmation of AgNPs production in the reaction mixture was witnessed by the colour change and surface resonance plasmon (SRP) band at 410nm by UV-visible spectroscopy. The morphology, size, crystalline nature, and elemental composition of attained AgNPs were further confirmed by the transmission electron microscopy (TEM), selected area electron diffraction (SAED), X-ray diffraction (XRD) technique, Scanning electron microscopy (SEM) and energy dispersive spectroscopy (EDS). The functional groups of AgNPs with stabilization/capped phytochemicals were detected by Fourier-transform infrared spectroscopy (FTIR). Further, antibiofilm activity of synthesized AgNPs against biofilm producers such as Staphylococcus aureus, Escherichia coli and Pseudomonas aeruginosa were determined by viability assays and micrographically. AgNPs coated and coating-free catheters performed to treat with bacterial pathogen to analyze the mat formation and disruption of biofilm formation. Synergistic effect of AgNPs with antibiotic reveals that it can enhance the activity of antibiotics, AgNPs coated catheter revealed that, it has potential antimicrobial activity and antibiofilm activity. In summary, C. carandas leaf extract mediated synthesized AgNPs will open a new avenue and a promising template to embed on urinary catheter to control clinical pathogens.
      Competing Interests: The authors have declared that no competing interests exist.
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    • Accession Number:
      0 (Anti-Bacterial Agents)
      0 (Gentamicins)
      0 (Phytochemicals)
      0 (Plant Extracts)
      3M4G523W1G (Silver)
      5E8K9I0O4U (Ciprofloxacin)
      AN164J8Y0X (Trimethoprim)
    • Publication Date:
      Date Created: 20210902 Date Completed: 20211116 Latest Revision: 20211116
    • Publication Date:
      20240105
    • Accession Number:
      PMC8412375
    • Accession Number:
      10.1371/journal.pone.0256748
    • Accession Number:
      34473763