Up-regulation expression and prognostic significance of Syntaxin4 in kidney renal clear cell carcinoma.

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  • Additional Information
    • Source:
      Publisher: BioMed Central Country of Publication: England NLM ID: 100967800 Publication Model: Electronic Cited Medium: Internet ISSN: 1471-2407 (Electronic) Linking ISSN: 14712407 NLM ISO Abbreviation: BMC Cancer Subsets: MEDLINE
    • Publication Information:
      Original Publication: London : BioMed Central, [2001-
    • Subject Terms:
      Biomarkers, Tumor/*metabolism ; Carcinoma, Renal Cell/*pathology ; Kidney Neoplasms/*pathology ; Qa-SNARE Proteins/*metabolism; Carcinoma, Renal Cell/metabolism ; Female ; Follow-Up Studies ; Humans ; Kidney Neoplasms/metabolism ; Male ; Middle Aged ; Prognosis ; Survival Rate
    • Abstract:
      Background: Syntaxin4 (STX4) gene encodes the protein STX4, a member of soluble N-ethylmaleimide-sensitive factor attachment protein receptors protein, playing a vital role in cell invadopodium formation and invasion, which is associated with the malignant progression of various human cancers. However, the expression and prognostic significance of STX4 in kidney renal clear cell carcinoma (KIRC) remain to be investigated.
      Methods: In this study, we collected the mRNA expression of STX4 in 535 KIRC patients from The Cancer Genome Atlasthrough the University of California Santa Cruz Xena database platform. Then we explored the expression of STX4 in KIRC, and the relationship with clinicopathological characteristics and prognostic value. Gene Ontology and Kyoto Encyclopedia of Genes and Genomes function enrichment analyses were used to explore the potential mechanism of STX4 in KIRC. qRT-PCR analysis was performed toverify the above results with real world tissue specimens.
      Results: The results indicated that STX4 was up-expressed in KIRC, and were associated with higher histological grade, advanced stage, and poorer prognosis. Moreover, elevated STX4 expression is an independent risk factor for KIRC. qRT-PCR analysis showed that STX4 was significantly elevated in 10 paired of KIRC samples compared to normal samples. Functional enrichment analysis indicated that endo/exocytosis, autophagy, mTOR signaling pathway, and NOD-like receptor signaling pathway were enriched.
      Conclusions: In summary, STX4 is constantly up-expressed in KIRC tissues, associated with a poor prognosis. We suggest that it can be an effective biomarker for the prognosis of KIRC and may be a novel therapeutic target in KIRC.
      (© 2021. The Author(s).)
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    • Contributed Indexing:
      Keywords: Cell invasion; Endo/exocytosis; Kidney renal clear cell carcinoma; Prognostic; Syntaxin4
    • Accession Number:
      0 (Biomarkers, Tumor)
      0 (Qa-SNARE Proteins)
      0 (syntaxin 4, human)
    • Publication Date:
      Date Created: 20210906 Date Completed: 20211018 Latest Revision: 20211018
    • Publication Date:
      20240105
    • Accession Number:
      PMC8420070
    • Accession Number:
      10.1186/s12885-021-08736-1
    • Accession Number:
      34482824