Deformability of Stored Red Blood Cells.

Publisher: Frontiers Research Foundation Country of Publication: Switzerland NLM ID: 101549006 Publication Model: eCollection Cited Medium: Print ISSN: 1664-042X (Print) Linking ISSN: 1664042X NLM ISO Abbreviation: Front Physiol Subsets: PubMed not MEDLINE

Original Publication: Lausanne : Frontiers Research Foundation

Red blood cells (RBCs) deformability refers to the cells' ability to adapt their shape to the dynamically changing flow conditions so as to minimize their resistance to flow. The high red cell deformability enables it to pass through small blood vessels and significantly determines erythrocyte survival. Under normal physiological states, the RBCs are attuned to allow for adequate blood flow. However, rigid erythrocytes can disrupt the perfusion of peripheral tissues and directly block microvessels. Therefore, RBC deformability has been recognized as a sensitive indicator of RBC functionality. The loss of deformability, which a change in the cell shape can cause, modification of cell membrane or a shift in cytosol composition, can occur due to various pathological conditions or as a part of normal RBC aging ( in vitro or in vivo ). However, despite extensive research, we still do not fully understand the processes leading to increased cell rigidity under cold storage conditions in a blood bank ( in vitro aging), In the present review, we discuss publications that examined the effect of RBCs' cold storage on their deformability and the biological mechanisms governing this change. We first discuss the change in the deformability of cells during their cold storage. After that, we consider storage-related alterations in RBCs features, which can lead to impaired cell deformation. Finally, we attempt to trace a causal relationship between the observed phenomena and offer recommendations for improving the functionality of stored cells.
Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
(Copyright © 2021 Barshtein, Pajic-Lijakovic and Gural.)

Sci Rep. 2017 Aug 10;7(1):7846. (PMID: 28798476)
Haematologica. 2012 Jan;97(1):107-15. (PMID: 21993682)
Blood. 1990 Jan 1;75(1):266-70. (PMID: 2294990)
Front Physiol. 2021 Mar 02;12:639722. (PMID: 33737886)
Proc Natl Acad Sci U S A. 2007 Oct 23;104(43):17063-8. (PMID: 17940021)
Transfusion. 2008 May;48(5):827-35. (PMID: 18346024)
Biophys J. 1999 Dec;77(6):3085-95. (PMID: 10585930)
Front Physiol. 2021 Mar 15;12:655393. (PMID: 33790808)
Transfusion. 2008 Sep;48(9):1943-53. (PMID: 18564399)
Microsyst Nanoeng. 2019 Nov 4;5:51. (PMID: 31700671)
Blood Transfus. 2017 Mar;15(2):116-125. (PMID: 28263168)
Am J Hematol. 2017 Sep;92(9):E559-E560. (PMID: 28614898)
Front Med (Lausanne). 2018 May 15;5:130. (PMID: 29868587)
Mil Med. 2015 Mar;180(3 Suppl):150-7. (PMID: 25747646)
Blood. 2015 Jan 15;125(3):542-52. (PMID: 25411427)
Transfusion. 2015 Jan;55(1):205-19. (PMID: 25130459)
Transfus Clin Biol. 2010 Sep;17(3):87-94. (PMID: 20655268)
Front Physiol. 2018 Jun 01;9:656. (PMID: 29910743)
Am J Hematol. 2013 Aug;88(8):682-9. (PMID: 23674388)
Lab Chip. 2020 Jan 21;20(2):226-235. (PMID: 31796943)
Front Physiol. 2020 Jan 21;10:1613. (PMID: 32038293)
Crit Care Med. 2013 Mar;41(3):842-9. (PMID: 23314580)
Blood Transfus. 2014 Apr;12(2):204-9. (PMID: 24120596)
Blood Adv. 2018 Oct 23;2(20):2581-2587. (PMID: 30305267)
Clin Hemorheol Microcirc. 2009;43(4):283-98. (PMID: 19996518)
Transfus Apher Sci. 2020 Oct;59(5):102876. (PMID: 32690367)
Transfusion. 2016 Apr;56(4):980-93. (PMID: 26662506)
Sci Rep. 2021 Jan 12;11(1):604. (PMID: 33436749)
Br J Haematol. 1989 Jan;71(1):131-6. (PMID: 2492818)
Scand J Clin Lab Invest. 2015 May;75(3):213-22. (PMID: 25594795)
Am J Hematol. 2019 Feb;94(2):189-199. (PMID: 30417938)
Vox Sang. 2008 Nov;95(4):280-7. (PMID: 19138257)
Science. 1984 Jan 27;223(4634):400-3. (PMID: 6362007)
Biomech Model Mechanobiol. 2014 Oct;13(5):1097-104. (PMID: 24535085)
Blood Transfus. 2010 Jun;8 Suppl 3:s48-52. (PMID: 20606749)
Transfusion. 2021 Mar;61(3):903-918. (PMID: 33381865)
Lab Chip. 2014 Feb 7;14(3):577-83. (PMID: 24296983)
Transfus Med Hemother. 2018 May;45(3):185-193. (PMID: 29928174)
Front Med (Lausanne). 2018 Apr 09;5:84. (PMID: 29686986)
Transfusion. 2008 Jul;48(7):1478-85. (PMID: 18482180)
J Lab Clin Med. 1969 May;73(5):722-33. (PMID: 5779258)
Transfus Med Hemother. 2012 Aug;39(4):277-282. (PMID: 22969698)
Lab Chip. 2020 Jun 21;20(12):2086-2099. (PMID: 32427268)
Front Physiol. 2021 Jan 13;11:603633. (PMID: 33519509)
JCI Insight. 2021 Feb 8;6(3):. (PMID: 33351786)
Bioelectrochemistry. 2004 May;62(2):191-3. (PMID: 15039026)
J Biomech. 2015 Nov 26;48(15):4065-4072. (PMID: 26477408)
Exp Hematol. 2010 Apr;38(4):282-91. (PMID: 20146933)
Pathophysiol Haemost Thromb. 2002 Sep-Dec;32(5-6):263-8. (PMID: 13679654)
Transfus Med Hemother. 2021 Feb;48(1):39-47. (PMID: 33708051)
Transfus Med Hemother. 2015 May;42(3):140-8. (PMID: 26195927)
Blood. 2001 Feb 15;97(4):1141-3. (PMID: 11159550)
Transfusion. 2020 Nov;60(11):2633-2646. (PMID: 32812244)
Transfusion. 2014 Mar;54(3 Pt 2):933-41. (PMID: 24660765)
Proc Natl Acad Sci U S A. 2009 Sep 8;106(36):15320-5. (PMID: 19717437)
Transfusion. 2020 Jun;60(6):1175-1182. (PMID: 32358816)
Biomed Biochim Acta. 1989;48(8):561-7. (PMID: 2619727)
J Lab Clin Med. 1966 Jun;67(6):955-65. (PMID: 5916144)
Clin Hemorheol Microcirc. 2014;57(3):275-89. (PMID: 23603326)
Semin Hematol. 1993 Jul;30(3):171-92. (PMID: 8211222)
Biophys J. 1983 Jul;43(1):63-73. (PMID: 6882863)
Proteomes. 2020 Mar 31;8(2):. (PMID: 32244435)
J Cell Biol. 1998 Aug 24;142(4):989-1000. (PMID: 9722611)
Transfus Med Hemother. 2017 Jun;44(3):183-187. (PMID: 28626369)
Transfusion. 2010 Apr;50(4):941-8. (PMID: 20003060)
J Biol Chem. 2012 Feb 3;287(6):4129-38. (PMID: 22147703)
Clin Hemorheol Microcirc. 2021;77(4):395-410. (PMID: 33386795)
Transfusion. 2011 Jul;51(7):1574-9. (PMID: 21251004)
Blood Adv. 2020 Nov 10;4(21):5527-5539. (PMID: 33166402)
Phys Biol. 2008 Aug 13;5(3):036007. (PMID: 18698116)
Proc Natl Acad Sci U S A. 2018 Sep 18;115(38):9574-9579. (PMID: 30190436)
Eur Biophys J. 2004 Feb;33(1):1-15. (PMID: 13680208)
Front Physiol. 2013 Dec 18;4:376. (PMID: 24391593)
Crit Care Med. 2005 Jan;33(1):39-45; discussion 238-9. (PMID: 15644646)
Anesth Analg. 2013 May;116(5):975-981. (PMID: 23449853)
Transfus Apher Sci. 2020 Oct;59(5):102851. (PMID: 32571640)
Blood Transfus. 2012 May;10 Suppl 2:s12-8. (PMID: 22890263)
Br J Haematol. 2008 May;141(3):367-75. (PMID: 18341630)
Proc Natl Acad Sci U S A. 2016 Jul 12;113(28):7804-9. (PMID: 27354532)
Front Physiol. 2018 Jul 24;9:914. (PMID: 30087617)
Cell Physiol Biochem. 2017;42(3):1139-1152. (PMID: 28668958)
Nat Rev Immunol. 2005 Aug;5(8):606-16. (PMID: 16056254)
Exp Cell Res. 2015 Oct 1;337(2):192-201. (PMID: 26169694)
Expert Rev Cardiovasc Ther. 2007 Jul;5(4):743-52. (PMID: 17605652)
Transfusion. 2008 Jan;48(1):136-46. (PMID: 17900281)
Clin Hemorheol Microcirc. 2009;42(1):47-64. (PMID: 19363240)
Clin Hemorheol Microcirc. 1998 Dec;19(4):315-25. (PMID: 9972669)
Vox Sang. 2000;79(2):75-82. (PMID: 11054044)
J Theor Biol. 1995 Aug 21;175(4):517-24. (PMID: 7475087)
J Proteomics. 2012 Dec 5;76 Spec No.:168-80. (PMID: 22465715)
J Clin Invest. 1969 May;48(5):795-809. (PMID: 4388591)
Biochim Biophys Acta Biomembr. 2020 Jun 1;1862(6):183231. (PMID: 32119860)
Am J Physiol. 1999 Dec;277(6):H2145-57. (PMID: 10600832)
Biopolymers. 2008 Nov;89(11):951-9. (PMID: 18615496)
Lab Chip. 2013 Jul 7;13(13):2464-83. (PMID: 23681312)
Infect Immun. 2014 Jun;82(6):2532-41. (PMID: 24686065)
Microcirculation. 2020 Oct;27(7):e12649. (PMID: 32663357)
Crit Care Med. 2007 Jul;35(7):1639-44. (PMID: 17522571)
Vox Sang. 2014 Jul;107(1):1-9. (PMID: 24446817)
Transfusion. 2021 Feb;61(2):435-448. (PMID: 33146433)
Transfusion. 2017 Apr;57(4):1019-1030. (PMID: 28295356)
Oxid Med Cell Longev. 2010 Jan-Feb;3(1):2-12. (PMID: 20716923)
Transfusion. 2018 Sep;58(9):2217-2226. (PMID: 30168148)
Hematology Am Soc Hematol Educ Program. 2020 Dec 4;2020(1):160-166. (PMID: 33275743)
J Lab Clin Med. 1969 Aug;74(2):300-4. (PMID: 5799513)
Transfusion. 2016 May;56(5):1101-11. (PMID: 26825863)
Cell Physiol Biochem. 2005;16(4-6):133-46. (PMID: 16301814)
Transfusion. 2008 Mar;48(3):451-62. (PMID: 18067507)
Blood. 2011 Feb 24;117(8):e88-95. (PMID: 21163923)
Exp Biol Med (Maywood). 2020 Jan;245(2):155-165. (PMID: 31948290)
Phys Rev Lett. 1995 Feb 13;74(7):1250-1253. (PMID: 10058972)
Biomed Biochim Acta. 1985;44(10):1459-67. (PMID: 4084251)
Opt Express. 2007 Dec 10;15(25):17001-9. (PMID: 19550991)
Clin Hemorheol Microcirc. 2014;56(4):337-45. (PMID: 23818106)
Ann Thorac Surg. 2019 Nov;108(5):1587-1588. (PMID: 30953649)
Biomicrofluidics. 2014 Sep 17;8(5):051501. (PMID: 25332724)
PLoS One. 2019 Oct 22;14(10):e0224036. (PMID: 31639179)
Transfus Med. 2000 Dec;10(4):291-303. (PMID: 11123813)
Biomed Res Int. 2014;2014:764268. (PMID: 25295273)
Microcirculation. 2016 Oct;23(7):479-486. (PMID: 27406436)
Front Immunol. 2017 Feb 02;8:73. (PMID: 28210260)
Transfus Clin Biol. 2015 Aug;22(3):151-7. (PMID: 26138907)
Transfus Apher Sci. 2020 Jun;59(3):102738. (PMID: 32051099)
Transfus Med Hemother. 2014 Jun;41(3):197-204. (PMID: 25053933)
Ann Thorac Surg. 2019 Mar;107(3):973-980. (PMID: 30342044)
Lancet. 1954 Jan 16;266(6803):119-24. (PMID: 13118742)
Blood Transfus. 2021 May;19(3):224-236. (PMID: 33085592)
J Cardiothorac Vasc Anesth. 2019 Nov;33(11):2960-2967. (PMID: 31072700)
Proteomics Clin Appl. 2016 Aug;10(8):791-804. (PMID: 27095294)
Transfusion. 2019 May;59(5):1620-1623. (PMID: 30865302)
J Bioenerg Biomembr. 2015 Dec;47(6):507-18. (PMID: 26560902)
Microcirculation. 1996 Mar;3(1):49-57. (PMID: 8846271)
Front Physiol. 2018 Jan 30;9:41. (PMID: 29441026)
Semin Thromb Hemost. 2003 Oct;29(5):435-50. (PMID: 14631543)
Jpn J Physiol. 1986;36(6):1125-39. (PMID: 3599550)
Transfusion. 2010 Feb;50(2):376-89. (PMID: 19874562)
J Proteome Res. 2007 Aug;6(8):3242-55. (PMID: 17585793)

Keywords: RBC deformability; RBC storage; RBC storage lesion; red blood cells; transfusion

Date Created: 20211025 Latest Revision: 20211026

20240105

PMC8530101

10.3389/fphys.2021.722896

34690797