Breast cancer glycan biomarkers: their link to tumour cell metabolism and their perspectives in clinical practice.

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  • Additional Information
    • Source:
      Publisher: Informa Healthcare Country of Publication: England NLM ID: 101223548 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1744-8387 (Electronic) Linking ISSN: 14789450 NLM ISO Abbreviation: Expert Rev Proteomics Subsets: MEDLINE
    • Publication Information:
      Publication: June 2013- : London : Informa Healthcare
      Original Publication: London : Future Drugs Ltd., [2004]-
    • Subject Terms:
    • Abstract:
      Introduction: Breast cancer (BCa) is the most common cancer type diagnosed in women and 5 th most common cause of deaths among all cancer deaths despite the fact that screening program is at place. This is why novel diagnostics approaches are needed in order to decrease number of BCa cases and disease mortality.
      Areas Covered: In this review paper, we aim to cover some basic aspects regarding cellular metabolism and signalling in BCa behind altered glycosylation. We also discuss novel exciting discoveries regarding glycan-based analysis, which can provide useful information for better understanding of the disease. The final part deals with clinical usefulness of glycan-based biomarkers and the clinical performance of such biomarkers is compared to already approved BCa biomarkers and diagnostic tools based on imaging.
      Expert Opinion: Recent discoveries suggest that glycan-based biomarkers offer high accuracy for possible BCa diagnostics in blood, but also for better monitoring and management of BCa patients. The review article was written using Web of Science search engine to include articles published between 2019 and 2021.
    • Contributed Indexing:
      Keywords: Breast cancer; diagnostics; glycans; glycomics; lectins; mass spectrometry; prognosis; receiver operating curve
    • Accession Number:
      0 (Biomarkers)
      0 (Biomarkers, Tumor)
      0 (Polysaccharides)
    • Publication Date:
      Date Created: 20211029 Date Completed: 20220202 Latest Revision: 20220202
    • Publication Date:
      20240105
    • Accession Number:
      10.1080/14789450.2021.1996231
    • Accession Number:
      34711108