The Anticonvulsant Lamotrigine Reduces Bout-Like Alcohol Drinking in Rats.

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  • Additional Information
    • Source:
      Publisher: Oxford University Press Country of Publication: England NLM ID: 8310684 Publication Model: Print Cited Medium: Internet ISSN: 1464-3502 (Electronic) Linking ISSN: 07350414 NLM ISO Abbreviation: Alcohol Alcohol Subsets: MEDLINE
    • Publication Information:
      Publication: <2003- > : Oxford : Oxford University Press
      Original Publication: Oxford ; New York : Pergamon Press, c1983-
    • Subject Terms:
      Alcohol Drinking*/drug therapy ; Anticonvulsants*/pharmacology ; Anticonvulsants*/therapeutic use; Animals ; Ethanol ; Lamotrigine ; Rats
    • Abstract:
      We used an optical lickometer system to study drinking microstructure and effect of lamotrigine in voluntary alcohol-drinking rats. We showed that, similar to humans, animals differ by their drinking microstructure where some consume alcohol exclusively in a bout-like patterns. The study suggests that anticonvulsants, such as lamotrigine, may be one treatment strategy specifically affecting this type of drinking.
      (© The Author(s) 2021. Medical Council on Alcohol and Oxford University Press. All rights reserved.)
    • Grant Information:
      MIP-012/2014 Research Council of Lithuania; S-01.2.1-LVPA-K-856-01-0222 Lithuanian Business Support Agency
    • Accession Number:
      0 (Anticonvulsants)
      3K9958V90M (Ethanol)
      U3H27498KS (Lamotrigine)
    • Publication Date:
      Date Created: 20211031 Date Completed: 20220316 Latest Revision: 20220316
    • Publication Date:
      20240105
    • Accession Number:
      10.1093/alcalc/agab073
    • Accession Number:
      34718391