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Genomic Characterization of Group A Streptococci Causing Pharyngitis and Invasive Disease in Colorado, USA, June 2016- April 2017.
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- Author(s): Li Y;Li Y; Dominguez S; Dominguez S; Dominguez S; Nanduri SA; Nanduri SA; Rivers J; Rivers J; Mathis S; Mathis S; Li Z; Li Z; McGee L; McGee L; Chochua S; Chochua S; Metcalf BJ; Metcalf BJ; Van Beneden CA; Van Beneden CA; Beall B; Beall B; Miller L; Miller L
- Source:
The Journal of infectious diseases [J Infect Dis] 2022 May 16; Vol. 225 (10), pp. 1841-1851.- Publication Type:
Journal Article; Research Support, U.S. Gov't, P.H.S.- Language:
English - Source:
- Additional Information
- Source: Publisher: Oxford University Press Country of Publication: United States NLM ID: 0413675 Publication Model: Print Cited Medium: Internet ISSN: 1537-6613 (Electronic) Linking ISSN: 00221899 NLM ISO Abbreviation: J Infect Dis Subsets: MEDLINE
- Publication Information: Publication: Jan. 2011- : Oxford : Oxford University Press
Original Publication: 1904-2010 : Chicago, IL : University of Chicago Press - Subject Terms: Pharyngitis*/drug therapy ; Pharyngitis*/epidemiology ; Streptococcal Infections*/drug therapy ; Streptococcal Infections*/epidemiology; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/therapeutic use ; Colorado/epidemiology ; Drug Resistance, Bacterial/genetics ; Genomics ; Humans ; Streptococcus pyogenes
- Abstract: Background: The genomic features and transmission link of circulating Group A Streptococcus (GAS) strains causing different disease types, such as pharyngitis and invasive disease, are not well understood.
Methods: We used whole-genome sequencing to characterize GAS isolates recovered from persons with pharyngitis and invasive disease in the Denver metropolitan area from June 2016 to April 2017.
Results: The GAS isolates were cultured from 236 invasive and 417 pharyngitis infections. Whole-genome sequencing identified 34 emm types. Compared with pharyngitis isolates, invasive isolates were more likely to carry the erm family genes (23% vs 7.4%, P<.001), which confer resistance to erythromycin and clindamycin (including inducible resistance), and covS gene inactivation (7% vs 0.5%, P<.001). Whole-genome sequencing identified 97 genomic clusters (433 isolates; 2-65 isolates per cluster) that consisted of genomically closely related isolates (median single-nucleotide polymorphism=3 [interquartile range, 1-4] within cluster). Thirty genomic clusters (200 isolates; 31% of all isolates) contained both pharyngitis and invasive isolates and were found in 11 emm types.
Conclusions: In the Denver metropolitan population, mixed disease types were commonly seen in clusters of closely related isolates, indicative of overlapping transmission networks. Antibiotic-resistance and covS inactivation was disproportionally associated with invasive disease.
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- Contributed Indexing: Keywords: Group A streptococcus; antimicrobial resistance; genomic cluster; invasive disease; pharyngitis
- Accession Number: 0 (Anti-Bacterial Agents)
- Publication Date: Date Created: 20211117 Date Completed: 20220519 Latest Revision: 20230517
- Publication Date: 20240105
- Accession Number: PMC9125432
- Accession Number: 10.1093/infdis/jiab565
- Accession Number: 34788828
- Source:
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