Infection and transmission of ancestral SARS-CoV-2 and its alpha variant in pregnant white-tailed deer.

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  • Additional Information
    • Source:
      Publisher: Taylor & Francis Country of Publication: United States NLM ID: 101594885 Publication Model: Print Cited Medium: Internet ISSN: 2222-1751 (Electronic) Linking ISSN: 22221751 NLM ISO Abbreviation: Emerg Microbes Infect Subsets: MEDLINE
    • Publication Information:
      Publication: 2019- : [Philadelphia, PA] : Taylor & Francis
      Original Publication: New York : NPG, 2012-2018.
    • Subject Terms:
    • Abstract:
      ABSTRACT SARS-CoV-2 was first reported circulating in human populations in December 2019 and has since become a global pandemic. Recent history involving SARS-like coronavirus outbreaks have demonstrated the significant role of intermediate hosts in viral maintenance and transmission. Evidence of SARS-CoV-2 natural infection and experimental infections of a wide variety of animal species has been demonstrated, and in silico and in vitro studies have indicated that deer are susceptible to SARS-CoV-2 infection. White-tailed deer (WTD) are amongst the most abundant and geographically widespread wild ruminant species in the US. Recently, WTD fawns were shown to be susceptible to SARS-CoV-2. In the present study, we investigated the susceptibility and transmission of SARS-CoV-2 in adult WTD. In addition, we examined the competition of two SARS-CoV-2 isolates, representatives of the ancestral lineage A and the alpha variant of concern (VOC) B.1.1.7 through co-infection of WTD. Next-generation sequencing was used to determine the presence and transmission of each strain in the co-infected and contact sentinel animals. Our results demonstrate that adult WTD are highly susceptible to SARS-CoV-2 infection and can transmit the virus through direct contact as well as vertically from doe to fetus. Additionally, we determined that the alpha VOC B.1.1.7 isolate of SARS-CoV-2 outcompetes the ancestral lineage A isolate in WTD, as demonstrated by the genome of the virus shed from nasal and oral cavities from principal infected and contact animals, and from the genome of virus present in tissues of principal infected deer, fetuses and contact animals.
    • Comments:
      Update of: bioRxiv. 2021 Aug 16;:. (PMID: 34426811)
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    • Grant Information:
      75N93021C00016 United States AI NIAID NIH HHS; HHSN272201400006C United States AI NIAID NIH HHS; HHSN272201400008C United States AI NIAID NIH HHS; P20 GM130448 United States GM NIGMS NIH HHS
    • Contributed Indexing:
      Keywords: SARS-CoV-2; cervid; co-infection; pregnancy; susceptibility; transmission; white-tailed deer
    • Accession Number:
      0 (Antibodies, Neutralizing)
      0 (Antibodies, Viral)
      0 (RNA, Viral)
    • Subject Terms:
      SARS-CoV-2 variants
    • Publication Date:
      Date Created: 20211129 Date Completed: 20211231 Latest Revision: 20231105
    • Publication Date:
      20240104
    • Accession Number:
      PMC8725908
    • Accession Number:
      10.1080/22221751.2021.2012528
    • Accession Number:
      34842046