Effect of glycolic acid and EDTA on dentin mechanical properties.

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  • Additional Information
    • Source:
      Publisher: Wiley-Blackwell Publishing Asia Country of Publication: Australia NLM ID: 100888004 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1747-4477 (Electronic) Linking ISSN: 13291947 NLM ISO Abbreviation: Aust Endod J
    • Publication Information:
      Publication: Richmond, VIC : Wiley-Blackwell Publishing Asia
      Original Publication: Melbourne, Vic. : Australian Society of Endodontology
    • Subject Terms:
    • Abstract:
      The aim of this study was to evaluate the effect of glycolic acid (GA) and EDTA on dentin mechanical properties. For the cohesive strength, flexural strength and fracture strength tests, the hourglass of root dentin, dentin sticks and roots standardised to 1 mm thickness were used respectively. ANOVA and Tukey tests were used for statistical analysis (P < 0.05). The results showed that EDTA and GA 17% reduced the cohesive strength values when compared to distilled water (control; P = 0.0022 and P = 0.0016 respectively), whereas the values for GA 10% group were similar to those of the control group (P = 0.093). No statistically significant difference was found among the groups for the flexural strength test (P = 0.1974). Fracture strength test showed that EDTA and GA 17% were statistically similar to each other (P = 0.7694) and statistically inferior to GA 10% (P = 0.0007 and P = 0.0004 respectively). It was concluded that 10% GA showed fewer negative effects on dentin mechanical properties.
      (© 2021 Australian Society of Endodontology Inc.)
    • References:
      Lottanti S, Gautchi H, Sener B, Zehnder M. Effects of ethylenediaminetetraacetic, etidronic and peracetic acid irrigation on human root dentine and the smear layer. Int Endod J 2009; 42: 335-43.
      Yang Y, Shein Y, Wang Z et al. Evaluation of the susceptibility of multispecies biofilms in dentinal tubules to disinfecting solutions. J Endod 2016; 42: 1246-50.
      Ye WH, Fan B, Purcell W et al. Anti-biofilm efficacy of root canal irrigants against in-situ Enterococcus faecalis biofilms in root canals, isthmuses and dentinal tubules. J Dent 2018; 79: 68-76.
      Morago A, Ordinola-Zapata R, Ferrer-Luque CM, Baca P, Ruiz-Linares M, Arias-Moliz MT. Influence of smear layer on the antimicrobial activity of a sodium hypochlorite/etidronic acid irrigating solution in infected dentin. J Endod 2016; 42: 1647-50.
      Cobankara FK, Adanr N, Belli S. Evaluation of the influence as smear layer on the apical and coronal sealing ability of two sealers. J Endod 2004; 30: 406-9.
      De-Deus G, Souza EM, Barino B et al. The self-adjusting file optimizes debridement quality in oval-shaped root canals. J Endod 2011; 37: 701-5.
      Qian W, Shein Y, Haapasalo M. Quantitative analysis of the effect of irrigant solution sequences on dentin erosion. J Endod 2011; 37: 1437-41.
      Torabinejad M, Khademi A, Babagol J et al. A new solution for the removal of the smear layer. J Endod 2003; 29: 170-5.
      Souza MA, Bischoff KF, Rigo BDC et al. Cytotoxicity of different concentrations of glycolic acid and its effects on root dentin microhardness - An in vitro study. Aust Endod J 2021; 1(1).
      Marending M, Paque F, Fischer J, Zehnder M. Impact of irrigant sequence on mechanical properties of human root dentin. J Endod 2007; 33: 1325-8.
      Godfrey PD, Rodgers FM, Brown RD. Theory versus experiment in jet spectroscopy: Glycolic acid. J Am Chem Soc 1997; 119: 2232-9.
      Green BA, Yu RJ, Van Scott EJ. Clinical and cosmeceutical uses of hydroxyacids. Clin Dermatol 2009; 27: 495-501.
      Tang SC, Yang JH. Dual effects of alpha-hydroxy acids on the skin. Molecules 2018; 23: 4-12.
      Cecchin D, Farina AP, Vidal CMP, Bredan-Russo AK. A novel enamel and dentin etching protocol using α-hydroxy glycolic acid: surface property, etching pattern, and bond strength studies. Oper Dent 2018; 43: 101-10.
      Barcellos DPDC, Farina AP, Barcellos R et al. Effect of a new irrigant solution containing glycolic acid on smear layer removal and chemical/mechanical properties of dentin. Sci Rep 2020; 10: 1-8.
      Bello YD, Porsh HF, Farina AP et al. Glycolic acid as the final irrigant in endodontics: Mechanical and cytotoxic effects. Mater Sci Eng C Mater Biol Appl 2019; 100: 323-9.
      Bello YD, Farina AP, Souza MA, Cecchin D. Glycolic acid: Characterization of a new final irrigant and effects on flexural strength and structural integrity of dentin. Mater Sci EngC Mater Biol Appl 2020; 106: 1-6.
      Belli S, Eraslan O, Eraslan O, Eskitascioglu M, Eskitascioglu G. Effects of NaOCl, EDTA and MTAD when applied to dentine on stress distribution in post restored roots with flared canals. Int Endod J 2014; 47: 1123-32.
      Eldeniz AU, Erdemir A, Belli S. Effect of EDTA and citric acid solutions on the microhardness and the roughness of human root canal dentin. J Endod 2005; 31: 107-10.
      Mai S, Kim YK, Arola DD et al. Differential aggressiveness of ethylenediamine tetraacetic acid in causing canal wall erosion in the presence of sodium hypochlorite. J Dent 2010; 38: 201-6.
      Zhang K, Kim YK, Cadenaro M et al. Effects of different exposure times and concentrations of sodium hypochlorite/ethylenediaminetetraacetic acid on the structural integrity of mineralized dentin. J Endod 2010; 36: 105-9.
      Uzunoglu E, Aktemur S, Uyanik MO, Durmaz V, Nagas E. Effect of ethylenediaminetetraacetic acid on root fracture with respect to concentration at different time exposures. J Endod 2012; 38: 1110-3.
      Basrani B, Haapasalo M. Update on endodontic irrigating solutions. Endod Topics 2012; 27: 74-102.
      Niu W, Yoshio T, Kobayashi C, Suda H. A scanning electron microscopic study of dentinal erosion by final irrigation with EDTA and NaOCl solutions. Int Endod J 2002; 35: 934-9.
      Fuller JL, Hohnson WW. Citric acid consumption and the human dentition. J Am Dent Assoc 1977; 95: 80-4.
      Trevelin LT, Villanueva J, Zamperini CA, Mathew MT, Matos AB, Bredan-Russo AK. Investigation of five α-hydroxy acids for enamel and dentin etching: Demineralization depth, resin adhesion and dentin enzymatic activity. Dent Mater 2019; 35: 900-8.
    • Grant Information:
      107118 Fundação Universidade de Passo Fundo; 17/2551-0001 019-1 Fundação de Amparo à Pesquisa do Estado do Rio Grande do Sul
    • Contributed Indexing:
      Keywords: smear layer; cohesive strength; flexural strength; fracture strength; glycolic acid
    • Accession Number:
      0 (Glycolates)
      0WT12SX38S (glycolic acid)
      9G34HU7RV0 (Edetic Acid)
    • Publication Date:
      Date Created: 20211221 Date Completed: 20220429 Latest Revision: 20220429
    • Publication Date:
      20240104
    • Accession Number:
      10.1111/aej.12606
    • Accession Number:
      34932249