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Low-concentration of trichloromethane and dichloroacetonitrile promote the plasmid-mediated horizontal transfer of antibiotic resistance genes.
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- Author(s): He K;He K; Xue B; Xue B; Yang X; Yang X; Wang S; Wang S; Li C; Li C; Zhang X; Zhang X; Zhao C; Zhao C; Wang X; Wang X; Qiu Z; Qiu Z; Shen Z; Shen Z; Wang J; Wang J
- Source:
Journal of hazardous materials [J Hazard Mater] 2022 Mar 05; Vol. 425, pp. 128030. Date of Electronic Publication: 2021 Dec 09.- Publication Type:
Journal Article; Research Support, Non-U.S. Gov't- Language:
English - Source:
- Additional Information
- Source: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 9422688 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-3336 (Electronic) Linking ISSN: 03043894 NLM ISO Abbreviation: J Hazard Mater Subsets: MEDLINE
- Publication Information: Original Publication: Amsterdam : Elsevier,
- Subject Terms:
- Abstract: Disinfection by-products (DBPs) are one of the unintended consequences of water disinfection that are commonly detected in various water environments. Although DBPs are known to induce antimicrobial resistance via stimulation of chromosomal mutations, it remains unclear whether low-concentration of DBPs could stimulate the conjugative transfer of antibiotic resistance genes (ARGs). The present study aimed to investigate the effect of two typical DBPs, namely trichloromethane (TCM) and dichloroacetonitrile (DCAN), on the conjugative transfer of RP4 plasmid in Escherichia coli genera. The results of the study demonstrated that exposure to low concentrations of TCM and DCAN significantly stimulated conjugative transfer of ARGs, wherein application of 25 μg/L of TCM and 10 μg/L of DCAN resulted in maximum fold change of ~5.5- and ~6.0-fold, respectively, at 16 h of exposure. Further, assessment of underlying mechanisms revealed the involvement of intracellular reactive oxygen species generation, SOS response, increase in cell membrane permeability, upregulation of expression of genes and proteins related to pilus generation, ATP synthesis, and RP4 gene expression. Our findings provided a better understanding of the hidden biological effects and the ecological risks of DBPs in the water environment, especially concerning their effect on the spread of antibiotic resistance.
(Copyright © 2021 The Authors. Published by Elsevier B.V. All rights reserved.) - Contributed Indexing: Keywords: Antibiotic resistance genes; Conjugative transfer; Dichloroacetonitrile; Environmental concentration; Trichloromethane
- Accession Number: 0 (Acetonitriles)
0 (Anti-Bacterial Agents)
7V31YC746X (Chloroform)
O0L64V63M9 (dichloroacetonitrile) - Publication Date: Date Created: 20220106 Date Completed: 20220127 Latest Revision: 20220127
- Publication Date: 20240104
- Accession Number: 10.1016/j.jhazmat.2021.128030
- Accession Number: 34986571
- Source:
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