The effects of phytochemicals and herbal bio-active compounds on tumour necrosis factor-α in overweight and obese individuals: a clinical review.

Publisher: Birkhäuser Country of Publication: Switzerland NLM ID: 9112626 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1568-5608 (Electronic) Linking ISSN: 09254692 NLM ISO Abbreviation: Inflammopharmacology Subsets: MEDLINE

Publication: Basel ; Boston : Birkhäuser
Original Publication: Dordrecht, The Netherlands ; Norwell, MA, USA : Kluwer Academic Publishers, c1991-

Obesity*/drug therapy ; Obesity*/metabolism ; Overweight*/drug therapy ; Overweight*/metabolism ; Phytochemicals*/pharmacology ; Phytochemicals*/therapeutic use ; Tumor Necrosis Factor-alpha*/metabolism; Humans ; Insulin Resistance

Obesity is abnormal fat accumulation in the body which acts as a risk factor for various cardiometabolic states. Adipose tissue in excess can release inflammatory factors, including TNF-α and IL-6, and suppress adiponectin production. TNF-α increases the levels of IL-6 and acute phase reactants such as C-reactive protein. Inflammation has a crucial role in developing and progressing various cardiometabolic diseases and a wide range of obesity-related complications. It has been shown that TNF-α has a significant role in the development of insulin resistance. Recently, a growing body of evidence has focused on herbal medicine, phytochemicals and natural bioactive compounds as inexpensive, relatively easy accessible agents with low adverse effects to reduce inflammatory markers such as TNF-α and simultaneously decrease insulin resistance, glucose intolerance, and dyslipidemia in obesity. The main focus of the current review is to summarize the results of the studies, which assessed the effects of phytochemicals and herbal bio-active compounds on serum TNF-α in subjects with overweight or obesity. This review suggests that herbal medicine have favorable effects on the reduction of TNF-α concentration; however, the results were not uniform for different products. Among the reviewed plants, ginger, ginseng, resveratrol, and flaxseed had more promising effects.
(© 2021. The Author(s), under exclusive licence to Springer Nature Switzerland AG.)

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Keywords: Herbal medicine; Inflammation; Obesity; Phytochemicals; TNF-α; Tumour necrosis factor α

0 (Phytochemicals)
0 (Tumor Necrosis Factor-alpha)

Date Created: 20220108 Date Completed: 20220315 Latest Revision: 20220531

20240104

10.1007/s10787-021-00902-y

34997431