Association of the gut microbiome and metabolome with wheeze frequency in childhood asthma.

Item request has been placed! ×
Item request cannot be made. ×
loading   Processing Request
Read More Add to Saved list
  • Additional Information
    • Source:
      Publisher: Mosby Country of Publication: United States NLM ID: 1275002 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-6825 (Electronic) Linking ISSN: 00916749 NLM ISO Abbreviation: J Allergy Clin Immunol Subsets: MEDLINE
    • Publication Information:
      Original Publication: St Louis, Mosby.
    • Subject Terms:
      Asthma*/epidemiology ; Asthma*/metabolism ; Gastrointestinal Microbiome*/genetics ; Respiratory Sounds*; Child, Preschool ; Feces/microbiology ; Humans ; Metabolome ; Metabolomics/methods ; RNA, Ribosomal, 16S/genetics ; RNA, Ribosomal, 16S/metabolism
    • Abstract:
      Background: While the microbiome has an established role in asthma development, less is known about its contribution to morbidity in children with asthma.
      Objective: In this ancillary study of the Vitamin D Antenatal Asthma Reduction Trial (VDAART), we analyzed the gut microbiome and metabolome of wheeze frequency in children with asthma.
      Methods: Bacterial 16S ribosomal RNA microbiome and untargeted metabolomic profiling were performed on fecal samples collected from 3-year-old children with parent-reported physician-diagnosed asthma. We analyzed wheeze frequency by calculating the proportion of quarterly questionnaires administered between ages 3 and 5 years in which parents reported the child had wheezed (wheeze proportion). Taxa and metabolites associated with wheeze were analyzed by identifying log fold changes with respect to wheeze frequency and correlation/linear regression analyses, respectively. Microbe-metabolite and microbe-microbe correlation networks were compared between subjects with high and low wheeze proportion.
      Results: Specific taxa, including the genus Veillonella and histidine pathway metabolites, were enriched in subjects with high wheeze proportion. Among wheeze-associated taxa, Veillonella and Oscillospiraceae UCG-005, which was inversely associated with wheeze, were correlated with the greatest number of fecal metabolites. Microbial networks were similar between subjects with low versus high wheeze frequency.
      Conclusion: Gut microbiome features are associated with wheeze frequency in children with asthma, suggesting an impact of the gut microbiome on morbidity in childhood asthma.
      (Copyright © 2022 American Academy of Allergy, Asthma & Immunology. Published by Elsevier Inc. All rights reserved.)
    • References:
      Nature. 2014 Jun 5;510(7503):58-67. (PMID: 24899305)
      J Allergy Clin Immunol. 2016 Dec;138(6):1608-1618.e12. (PMID: 27777180)
      Methods Enzymol. 2013;531:237-50. (PMID: 24060124)
      Thorax. 2017 Mar;72(3):206-212. (PMID: 27999171)
      J Allergy Clin Immunol. 2007 Jan;119(1):73-80. (PMID: 17208587)
      Nutrients. 2020 Mar 22;12(3):. (PMID: 32235743)
      J Pharmacol Exp Ther. 2012 Aug;342(2):399-406. (PMID: 22570366)
      Mol Cell Pediatr. 2015 Dec;2(1):13. (PMID: 26637347)
      Nature. 2017 Nov 23;551(7681):507-511. (PMID: 29143816)
      Science. 2016 Apr 29;352(6285):560-4. (PMID: 27126039)
      Nat Biotechnol. 2019 Aug;37(8):852-857. (PMID: 31341288)
      J Allergy Clin Immunol. 2016 Nov;138(5):1491-1494.e7. (PMID: 27576125)
      J Allergy Clin Immunol. 2013 Feb;131(2):501-11.e1. (PMID: 22939756)
      ISME J. 2017 Feb;11(2):584-587. (PMID: 27612291)
      Cell. 2019 May 16;177(5):1217-1231.e18. (PMID: 31006530)
      Clin Chest Med. 2019 Mar;40(1):163-177. (PMID: 30691710)
      J Allergy Clin Immunol. 2013 Feb;131(2):346-52.e1-3. (PMID: 23265859)
      Am J Physiol Lung Cell Mol Physiol. 2008 Jun;294(6):L1085-93. (PMID: 18359884)
      Nat Commun. 2019 Jun 20;10(1):2719. (PMID: 31222023)
      MMWR Morb Mortal Wkly Rep. 2018 Feb 09;67(5):149-155. (PMID: 29420459)
      Nat Methods. 2016 Jul;13(7):581-3. (PMID: 27214047)
      PLoS Comput Biol. 2012;8(9):e1002687. (PMID: 23028285)
      PLoS One. 2012;7(2):e30126. (PMID: 22319561)
      Prim Care Respir J. 2012 Dec;21(4):398-404. (PMID: 22885561)
      Allergy. 2020 Aug;75(8):1991-2004. (PMID: 32072647)
      Sci Transl Med. 2013 May 22;5(186):186ra67. (PMID: 23698380)
      Am J Respir Crit Care Med. 2013 Nov 15;188(10):1193-201. (PMID: 24024497)
      PLoS Comput Biol. 2012;8(7):e1002606. (PMID: 22807668)
      J Allergy Clin Immunol. 2016 May;137(5):1398-1405.e3. (PMID: 26627545)
      J Allergy Clin Immunol. 2018 Aug;142(2):424-434.e10. (PMID: 29241587)
      Can Respir J. 2015 Jul-Aug;22(4):221-4. (PMID: 26083543)
      J Allergy Clin Immunol. 2011 Nov;128(5):948-55.e1-3. (PMID: 21872915)
      Curr Opin Clin Nutr Metab Care. 2017 Mar;20(2):99-103. (PMID: 28030368)
      JAMA. 2016 Jan 26;315(4):362-70. (PMID: 26813209)
      Nat Commun. 2019 Dec 16;10(1):5714. (PMID: 31844063)
      Allergy. 2019 May;74(5):899-909. (PMID: 30589936)
      J Asthma. 2004;41(8):833-43. (PMID: 15641633)
      J Allergy Clin Immunol. 2019 Aug;144(2):442-454. (PMID: 30914378)
      Science. 2016 Apr 29;352(6285):565-9. (PMID: 27126040)
      Allergy. 2020 Nov;75(11):2846-2857. (PMID: 32506557)
      Nat Genet. 2018 Jun;50(6):790-795. (PMID: 29808030)
      Nucleic Acids Res. 2013 Jan;41(Database issue):D590-6. (PMID: 23193283)
      PLoS One. 2016 Apr 14;11(4):e0152724. (PMID: 27078029)
      Ann Am Thorac Soc. 2014 Jan;11 Suppl 1:S48-51. (PMID: 24437406)
      Eur J Nutr. 2020 Jun;59(4):1553-1562. (PMID: 31147834)
      Lung. 2017 Dec;195(6):683-692. (PMID: 28849295)
      Microbiome. 2018 May 17;6(1):90. (PMID: 29773078)
      Front Immunol. 2020 Jan 21;10:3141. (PMID: 32038645)
      J Allergy Clin Immunol. 2011 Feb;127(2):372-381.e1-3. (PMID: 21194740)
      Nat Med. 2019 Jun;25(6):968-976. (PMID: 31171880)
      PLoS One. 2010 Jan 05;5(1):e8578. (PMID: 20052417)
      NAR Genom Bioinform. 2020 Jun;2(2):lqaa023. (PMID: 32391521)
      J Thorac Dis. 2021 Jul;13(7):4322-4338. (PMID: 34422359)
      Microbiome. 2016 Jun 21;4(1):28. (PMID: 27329048)
      Nat Med. 2016 Oct;22(10):1187-1191. (PMID: 27618652)
      Sci Transl Med. 2015 Sep 30;7(307):307ra152. (PMID: 26424567)
      Cochrane Database Syst Rev. 2012 May 16;(5):CD002314. (PMID: 22592685)
    • Grant Information:
      U01 HL091528 United States HL NHLBI NIH HHS; R01 DK125273 United States DK NIDDK NIH HHS; R01 HL123915 United States HL NHLBI NIH HHS; R01 HL141826 United States HL NHLBI NIH HHS; R01 HL108818 United States HL NHLBI NIH HHS; K08 HL148178 United States HL NHLBI NIH HHS; R01 AI141529 United States AI NIAID NIH HHS; UG3 OD023268 United States OD NIH HHS; UH3 OD023268 United States OD NIH HHS; K01 HL146980 United States HL NHLBI NIH HHS
    • Contributed Indexing:
      Keywords: Microbiome; asthma; metabolomics; wheeze
    • Accession Number:
      0 (RNA, Ribosomal, 16S)
    • Publication Date:
      Date Created: 20220223 Date Completed: 20220809 Latest Revision: 20230802
    • Publication Date:
      20240104
    • Accession Number:
      PMC9359927
    • Accession Number:
      10.1016/j.jaci.2022.02.005
    • Accession Number:
      35196534