Characterization of memory T cell subsets and common γ-chain cytokines in convalescent COVID-19 individuals.

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  • Additional Information
    • Source:
      Publisher: Oxford University Press Country of Publication: England NLM ID: 8405628 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1938-3673 (Electronic) Linking ISSN: 07415400 NLM ISO Abbreviation: J Leukoc Biol Subsets: MEDLINE
    • Publication Information:
      Publication: 2023- : Oxford : Oxford University Press
      Original Publication: New York : Alan R. Liss, c1984-
    • Subject Terms:
    • Abstract:
      T cells are thought to be an important correlates of protection against SARS-CoV2 infection. However, the composition of T cell subsets in convalescent individuals of SARS-CoV2 infection has not been well studied. The authors determined the lymphocyte absolute counts, the frequency of memory T cell subsets, and the plasma levels of common γ-chain in 7 groups of COVID-19 individuals, based on days since RT-PCR confirmation of SARS-CoV-2 infection. The data show that both absolute counts and frequencies of lymphocytes as well as, the frequencies of CD4 + central and effector memory cells increased, and the frequencies of CD4 + naïve T cells, transitional memory, stem cell memory T cells, and regulatory cells decreased from Days 15-30 to Days 61-90 and plateaued thereafter. In addition, the frequencies of CD8 + central memory, effector, and terminal effector memory T cells increased, and the frequencies of CD8 + naïve cells, transitional memory, and stem cell memory T cells decreased from Days 15-30 to Days 61-90 and plateaued thereafter. The plasma levels of IL-2, IL-7, IL-15, and IL-21-common γc cytokines started decreasing from Days 15-30 till Days 151-180. Severe COVID-19 patients exhibit decreased levels of lymphocyte counts and frequencies, higher frequencies of naïve cells, regulatory T cells, lower frequencies of central memory, effector memory, and stem cell memory, and elevated plasma levels of IL-2, IL-7, IL-15, and IL-21. Finally, there was a significant correlation between memory T cell subsets and common γc cytokines. Thus, the study provides evidence of alterations in lymphocyte counts, memory T cell subset frequencies, and common γ-chain cytokines in convalescent COVID-19 individuals.
      (© 2022 The Authors. Journal of Leukocyte Biology published by Wiley Periodicals LLC on behalf of Society for Leukocyte Biology.)
    • References:
      Med (N Y). 2021 Mar 12;2(3):281-295.e4. (PMID: 33589885)
      JAMA. 2020 Mar 17;323(11):1061-1069. (PMID: 32031570)
      Cell. 2008 May 30;133(5):775-87. (PMID: 18510923)
      J Infect. 2020 Aug;81(2):318-356. (PMID: 32283159)
      Science. 2020 Sep 4;369(6508):. (PMID: 32669297)
      PLoS One. 2007 Mar 21;2(3):e300. (PMID: 17375186)
      Signal Transduct Target Ther. 2020 Mar 27;5(1):33. (PMID: 32296069)
      Nat Commun. 2021 Feb 9;12(1):897. (PMID: 33563974)
      J Clin Invest. 2020 Dec 1;130(12):6588-6599. (PMID: 32841212)
      Nature. 2020 Aug;584(7821):463-469. (PMID: 32717743)
      Nat Med. 2020 Oct;26(10):1636-1643. (PMID: 32839624)
      Clin Exp Immunol. 1995 Aug;101(2):239-48. (PMID: 7544247)
      Science. 1996 Apr 5;272(5258):54-60. (PMID: 8600537)
      J Exp Med. 2001 Dec 17;194(12):1711-9. (PMID: 11748273)
      Lancet Respir Med. 2020 Apr;8(4):420-422. (PMID: 32085846)
      Sci Transl Med. 2016 Nov 30;8(367):367ra166. (PMID: 27903862)
      Am J Trop Med Hyg. 2021 Sep 27;105(5):1255-1260. (PMID: 34583334)
      Open Biol. 2020 Sep;10(9):200160. (PMID: 32961074)
      Cell. 2020 Oct 1;183(1):158-168.e14. (PMID: 32979941)
      Cell. 2020 Jun 25;181(7):1489-1501.e15. (PMID: 32473127)
      N Engl J Med. 2020 Apr 30;382(18):1708-1720. (PMID: 32109013)
      PLoS One. 2021 Jan 25;16(1):e0245532. (PMID: 33493185)
      J Leukoc Biol. 2022 Jul;112(1):201-212. (PMID: 35258122)
      Immunol Rev. 2018 May;283(1):176-193. (PMID: 29664568)
      Oxf Open Immunol. 2020 Dec 29;2(1):iqaa007. (PMID: 33575657)
      Immunity. 2008 Dec 19;29(6):848-62. (PMID: 19100699)
      Cytometry A. 2020 Apr;97(4):340-343. (PMID: 32187834)
      Sci Immunol. 2020 Jun 26;5(48):. (PMID: 32591408)
      Cell. 2021 Jan 7;184(1):169-183.e17. (PMID: 33296701)
      Nat Rev Immunol. 2020 Sep;20(9):529-536. (PMID: 32728222)
      Cytometry A. 2020 Aug;97(8):772-776. (PMID: 32542842)
      Nat Commun. 2021 Jun 30;12(1):4043. (PMID: 34193870)
      Int J Infect Dis. 2020 Jul;96:131-135. (PMID: 32376308)
      Biochem Biophys Res Commun. 2021 Jan 29;538:204-210. (PMID: 33220925)
      Science. 2021 Feb 5;371(6529):. (PMID: 33408181)
      Nat Rev Microbiol. 2009 Jun;7(6):439-50. (PMID: 19430490)
      Lancet. 2020 Feb 15;395(10223):497-506. (PMID: 31986264)
      Nat Rev Immunol. 2012 Feb 17;12(3):191-200. (PMID: 22343568)
      Front Immunol. 2020 May 01;11:827. (PMID: 32425950)
      Cytokine Growth Factor Rev. 2021 Apr;58:49-50. (PMID: 33199178)
      Sci Rep. 2021 Oct 12;11(1):20254. (PMID: 34642411)
      Int J Infect Dis. 2020 Sep;98:353-358. (PMID: 32634585)
      Sci Rep. 2020 Sep 28;10(1):15838. (PMID: 32985562)
      Cell Mol Immunol. 2020 May;17(5):541-543. (PMID: 32203186)
      Nat Rev Immunol. 2003 Apr;3(4):269-79. (PMID: 12669018)
      Eur J Immunol. 2004 Nov;34(11):2977-85. (PMID: 15384078)
      PLoS Negl Trop Dis. 2018 May 24;12(5):e0006481. (PMID: 29795573)
      Nat Immunol. 2020 Nov;21(11):1336-1345. (PMID: 32887977)
      J Clin Immunol. 2020 Oct;40(7):970-973. (PMID: 32594342)
      Nature. 2019 Nov;575(7781):119-129. (PMID: 31695203)
      Int Arch Allergy Immunol. 2021;182(3):254-262. (PMID: 33498051)
    • Contributed Indexing:
      Keywords: CD4+ T cell subsets; CD8+ T cell subsets; COVID-19, acute and convalescent COVID-19; Memory T cell subsets
    • Accession Number:
      0 (Cytokines)
      0 (Interleukin-15)
      0 (Interleukin-2)
      0 (Interleukin-7)
      0 (RNA, Viral)
    • Publication Date:
      Date Created: 20220308 Date Completed: 20220627 Latest Revision: 20220809
    • Publication Date:
      20240104
    • Accession Number:
      PMC9088480
    • Accession Number:
      10.1002/JLB.5COVA0721-392RR
    • Accession Number:
      35258122