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Characterization of memory T cell subsets and common γ-chain cytokines in convalescent COVID-19 individuals.
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- Author(s): Rajamanickam A;Rajamanickam A; Pavan Kumar N; Pavan Kumar N; Pandiaraj AN; Pandiaraj AN; Selvaraj N; Selvaraj N; Munisankar S; Munisankar S; Renji RM; Renji RM; Venkataramani V; Venkataramani V; Murhekar M; Murhekar M; Thangaraj JWV; Thangaraj JWV; Muthusamy SK; Muthusamy SK; Chethrapilly Purushothaman GK; Chethrapilly Purushothaman GK; Bhatnagar T; Bhatnagar T; Ponnaiah M; Ponnaiah M; Ramasamy S; Ramasamy S; Velusamy S; Velusamy S; Babu S; Babu S
- Source:
Journal of leukocyte biology [J Leukoc Biol] 2022 Jul; Vol. 112 (1), pp. 201-212. Date of Electronic Publication: 2022 Mar 08.- Publication Type:
Journal Article; Research Support, Non-U.S. Gov't- Language:
English - Source:
- Additional Information
- Source: Publisher: Oxford University Press Country of Publication: England NLM ID: 8405628 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1938-3673 (Electronic) Linking ISSN: 07415400 NLM ISO Abbreviation: J Leukoc Biol Subsets: MEDLINE
- Publication Information: Publication: 2023- : Oxford : Oxford University Press
Original Publication: New York : Alan R. Liss, c1984- - Subject Terms: COVID-19*/blood ; COVID-19*/immunology ; Cytokines*/blood ; Memory T Cells*/immunology; CD4-Positive T-Lymphocytes ; CD8-Positive T-Lymphocytes ; Convalescence ; Humans ; Immunologic Memory/immunology ; Interleukin-15/blood ; Interleukin-2/blood ; Interleukin-7/blood ; RNA, Viral ; SARS-CoV-2 ; T-Lymphocyte Subsets/immunology
- Abstract: T cells are thought to be an important correlates of protection against SARS-CoV2 infection. However, the composition of T cell subsets in convalescent individuals of SARS-CoV2 infection has not been well studied. The authors determined the lymphocyte absolute counts, the frequency of memory T cell subsets, and the plasma levels of common γ-chain in 7 groups of COVID-19 individuals, based on days since RT-PCR confirmation of SARS-CoV-2 infection. The data show that both absolute counts and frequencies of lymphocytes as well as, the frequencies of CD4 + central and effector memory cells increased, and the frequencies of CD4 + naïve T cells, transitional memory, stem cell memory T cells, and regulatory cells decreased from Days 15-30 to Days 61-90 and plateaued thereafter. In addition, the frequencies of CD8 + central memory, effector, and terminal effector memory T cells increased, and the frequencies of CD8 + naïve cells, transitional memory, and stem cell memory T cells decreased from Days 15-30 to Days 61-90 and plateaued thereafter. The plasma levels of IL-2, IL-7, IL-15, and IL-21-common γc cytokines started decreasing from Days 15-30 till Days 151-180. Severe COVID-19 patients exhibit decreased levels of lymphocyte counts and frequencies, higher frequencies of naïve cells, regulatory T cells, lower frequencies of central memory, effector memory, and stem cell memory, and elevated plasma levels of IL-2, IL-7, IL-15, and IL-21. Finally, there was a significant correlation between memory T cell subsets and common γc cytokines. Thus, the study provides evidence of alterations in lymphocyte counts, memory T cell subset frequencies, and common γ-chain cytokines in convalescent COVID-19 individuals.
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Int Arch Allergy Immunol. 2021;182(3):254-262. (PMID: 33498051) - Contributed Indexing: Keywords: CD4+ T cell subsets; CD8+ T cell subsets; COVID-19, acute and convalescent COVID-19; Memory T cell subsets
- Accession Number: 0 (Cytokines)
0 (Interleukin-15)
0 (Interleukin-2)
0 (Interleukin-7)
0 (RNA, Viral) - Publication Date: Date Created: 20220308 Date Completed: 20220627 Latest Revision: 20220809
- Publication Date: 20240104
- Accession Number: PMC9088480
- Accession Number: 10.1002/JLB.5COVA0721-392RR
- Accession Number: 35258122
- Source:
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