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Role of dense granule antigen 7 in vertical transmission of Neospora caninum in C57BL/6 mice infected during early pregnancy.
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- Author(s): Abdou AM;Abdou AM;Abdou AM; Ikeda R; Ikeda R; Watanabe K; Watanabe K; Furuoka H; Furuoka H; Nishikawa Y; Nishikawa Y
- Source:
Parasitology international [Parasitol Int] 2022 Aug; Vol. 89, pp. 102576. Date of Electronic Publication: 2022 Mar 15.- Publication Type:
Journal Article- Language:
English - Source:
- Additional Information
- Source: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 9708549 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-0329 (Electronic) Linking ISSN: 13835769 NLM ISO Abbreviation: Parasitol Int Subsets: MEDLINE
- Publication Information: Original Publication: Amsterdam ; New York : Elsevier, c1997-
- Subject Terms:
- Abstract: Neosporosis is a parasitic disease affecting the health of dogs and cattle worldwide. It is caused by Neospora caninum, an obligate intracellular apicomplexan parasite. Dogs are its definitive host, it mostly infects livestock animals, especially cattle that acts as intermediate host. It is necessary to have well-established models of abortion and vertical transmission in experimental animals, in order to determine basic control measures for the N. caninum infection. We evaluated the role of N. caninum dense granule antigen 7 (NcGRA7) in the vertical transmission of N. caninum using the C57BL/6 pregnant mouse model. We inoculated mice on day 3.5 of pregnancy with parental Nc-1 or NcGRA7-deficient parasites (NcGRA7KO). Post-mortem analyses were performed on day 30 after birth and the surviving pups were kept until day 30 postpartum. The number of parasites in the brain tissues of offspring from NcGRA7KO-infected dams was significantly lower than that of the Nc-1-infected dams under two infection doses (1 × 10 6 and 1 × 10 5 tachyzoites/mouse). The vertical transmission rates in the NcGRA7KO-infected group were significantly lower than those of the Nc1-infected group. To understand the mechanism by which the lack of NcGRA7 decreases the vertical transmission, pregnant mice were sacrificed on day 13.5 of pregnancy (10 days after infection), although parasite DNA was detected in the placentas, no significant difference was found between the two parasite lines. Histopathological analysis revealed a greater inflammatory response in the placentas from NcGRA7KO-infected dams than in those from the parental strain. This finding correlates with upregulated chemokine mRNA expression for CCL2, CCL8, and CXCL9 in the placentas from the NcGRA7KO-infected mice. In conclusion, these results suggest that loss of NcGRA7 triggers an inflammatory response in the placenta, resulting in decreased vertical transmission of N. caninum.
(Copyright © 2022 Elsevier B.V. All rights reserved.) - Contributed Indexing: Keywords: Brain; Chemokines; Inflammatory response; NcGRA7; Neosporosis; Placenta
- Accession Number: 0 (Antigens, Protozoan)
0 (Chemokines) - Publication Date: Date Created: 20220318 Date Completed: 20220524 Latest Revision: 20220602
- Publication Date: 20240105
- Accession Number: 10.1016/j.parint.2022.102576
- Accession Number: 35301119
- Source:
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