Dendritic Cell Differentiation from Human Induced Pluripotent Stem Cells: Challenges and Progress.

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  • Author(s): Oliveira NAJ;Oliveira NAJ; Sevim H; Sevim H
  • Source:
    Stem cells and development [Stem Cells Dev] 2022 May; Vol. 31 (9-10), pp. 207-220. Date of Electronic Publication: 2022 Apr 26.
  • Publication Type:
    Journal Article; Review; Research Support, Non-U.S. Gov't
  • Language:
    English
  • Additional Information
    • Source:
      Publisher: Mary Ann Liebert, Inc Country of Publication: United States NLM ID: 101197107 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1557-8534 (Electronic) Linking ISSN: 15473287 NLM ISO Abbreviation: Stem Cells Dev Subsets: MEDLINE
    • Publication Information:
      Original Publication: Larchmont, NY : Mary Ann Liebert, Inc., c2004-
    • Subject Terms:
      Induced Pluripotent Stem Cells*/metabolism; Bone Marrow ; Cell Differentiation/physiology ; Dendritic Cells ; Humans
    • Abstract:
      Dendritic cells (DCs) are the major antigen-presenting cells of the immune system responsible for initiating and coordinating immune responses. These abilities provide potential for several clinical applications, such as the development of immunogenic vaccines. However, difficulty in obtaining DCs from conventional sources, such as bone marrow, peripheral blood, and cord blood, significantly hinders routine application. The use of human induced pluripotent stem cells (hiPSCs) is a valuable alternative for generating sufficient numbers of DCs to be used in basic and preclinical studies. Despite the many challenges that must be overcome to achieve an efficient protocol for obtaining the major DC types from hiPSCs, recent progress has been made. In this study, we review the current state of developing DCs from hiPSCs, as well as the key elements required to enable the routine use of hiPSC-derived DCs in preclinical and clinical assays.
    • Contributed Indexing:
      Keywords: dendritic cells; differentiation; iPS
    • Publication Date:
      Date Created: 20220322 Date Completed: 20220517 Latest Revision: 20220624
    • Publication Date:
      20240104
    • Accession Number:
      10.1089/scd.2021.0305
    • Accession Number:
      35316109