The Association Between Metabolic Syndrome and Non-Alcoholic Fatty Liver Disease Diagnosis Varies by Race.

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  • Additional Information
    • Source:
      Publisher: Mary Ann Liebert, Inc Country of Publication: United States NLM ID: 101150318 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1557-8518 (Electronic) Linking ISSN: 15404196 NLM ISO Abbreviation: Metab Syndr Relat Disord Subsets: MEDLINE
    • Publication Information:
      Original Publication: Larchmont, NY : Mary Ann Liebert, Inc., c2003-
    • Subject Terms:
      Metabolic Syndrome*/complications ; Metabolic Syndrome*/diagnosis ; Metabolic Syndrome*/epidemiology ; Non-alcoholic Fatty Liver Disease*/complications ; Non-alcoholic Fatty Liver Disease*/diagnosis ; Non-alcoholic Fatty Liver Disease*/epidemiology; Adult ; Black or African American ; Aged ; Blood Glucose/metabolism ; Female ; Humans ; Male ; Middle Aged ; Retrospective Studies ; Risk Factors
    • Abstract:
      Objectives: This study investigated how the association between metabolic syndrome (MetS) and nonalcoholic fatty liver disease (NAFLD) diagnosis varies between non-Hispanic African American and white patients. Methods: A retrospective cohort study was performed using electronic medical records from an integrated health care system (2010-2018). Adults with records for all MetS measurements (body mass index, lipids, blood pressure, and blood glucose) in 2011, who did not have a NAFLD diagnosis before their last MetS measurement, were included. Results: The study cohort consisted of 139,336 patients (age 56.1 ± 15.2 years, 57.9% female, 79.4% non-Hispanic white). The rate of NAFLD diagnosis was higher in MetS patients compared with non-MetS patients [adjusted hazards ratio (AHR) = 1.99, 95% CI = 1.91-2.09] with a significant interaction by race (AHR = 2.05, 95% CI = 1.95-2.15 in non-Hispanic whites vs. AHR = 1.76, 95% CI = 1.58-1.96 non-Hispanic African Americans, P  = 0.017). Secondary analyses revealed that the relative NAFLD diagnosis rate was higher in non-Hispanic whites with MetS compared with non-Hispanic African Americans with MetS among females and patients 18-39 years of age and 40-59 years, but not among males and those ≥60 years of age. Conclusions: Non-Hispanic white patients with MetS, particularly females and those <60 years of age, may be at increased risk of NAFLD compared with non-Hispanic African American MetS patients and may benefit from extra attention regarding NAFLD screening.
    • Contributed Indexing:
      Keywords: African Americans; health care disparity; non-Hispanic whites; retrospective cohort study
    • Accession Number:
      0 (Blood Glucose)
    • Publication Date:
      Date Created: 20220323 Date Completed: 20220620 Latest Revision: 20221207
    • Publication Date:
      20240104
    • Accession Number:
      10.1089/met.2021.0108
    • Accession Number:
      35319282