Molecular Mechanisms Involved in Hypoxia-Induced Alterations in Bone Remodeling.

Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE

Original Publication: Basel, Switzerland : MDPI, [2000-

Bone Remodeling* ; Osteoclasts*/physiology; Cell Differentiation ; Humans ; Hypoxia ; Osteoblasts ; Osteogenesis/physiology

Bone is crucial for the support of muscles and the protection of vital organs, and as a reservoir of calcium and phosphorus. Bone is one of the most metabolically active tissues and is continuously renewed to adapt to the changes required for healthy functioning. To maintain normal cellular and physiological bone functions sufficient oxygen is required, as evidence has shown that hypoxia may influence bone health. In this scenario, this review aimed to analyze the molecular mechanisms involved in hypoxia-induced bone remodeling alterations and their possible clinical consequences. Hypoxia has been associated with reduced bone formation and reduced osteoblast matrix mineralization due to the hypoxia environment inhibiting osteoblast differentiation. A hypoxic environment is involved with increased osteoclastogenesis and increased bone resorptive capacity of the osteoclasts. Clinical studies, although with contradictory results, have shown that hypoxia can modify bone remodeling.

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Keywords: HIF; bone remodeling; hypoxia; osteoblast; osteoclast; oxygen

Date Created: 20220325 Date Completed: 20220408 Latest Revision: 20220408

20240104

PMC8953213

10.3390/ijms23063233

35328654