Blinding of interventions in clinical trials helps to prevent selection bias by making the allocation sequence difficult to decipher.

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  • Additional Information
    • Source:
      Publisher: Wiley-Blackwell Country of Publication: England NLM ID: 9609066 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1365-2753 (Electronic) Linking ISSN: 13561294 NLM ISO Abbreviation: J Eval Clin Pract Subsets: MEDLINE
    • Publication Information:
      Original Publication: Oxford, England : Wiley-Blackwell, c1995-
    • Subject Terms:
      Selection Bias* ; Clinical Trials as Topic*; Humans
    • References:
      Higgins JP, Altman DG, Gøtzsche PC, et al. The Cochrane Collaboration's tool for assessing risk of bias in randomised trials. BMJ. 2011;343:d5928. doi:10.1136/bmj.d5928.
      Sterne JAC, Savović J, Page MJ, et al. RoB 2: a revised tool for assessing risk of bias in randomised trials. BMJ. 2019;366:l4898. doi:10.1136/bmj.l4898.
      Centre for Evidence-Based Medicine. Catalogue of Bias. Accessed January 10, 2022. https://catalogofbias.org/.
      Sackett DL. Bias in analytical research. Chron Dis. 1979;32:51-63. doi:10.1016/0021-9681(79)90012-2.
      Senn S. Seven myths of randomisation in clinical trials. Stat Med. 2013;32(9):1439-1450. doi:10.1002/sim.5713.
      Chalmers I. Why the 1948 MRC trial of streptomycin used treatment allocation based on random numbers. J R Soc Med. 2011;104(9):383-386. doi:10.1258/jrsm.2011.11k023.
      Schulz KF, Chalmers I, Altman DG, Grimes DA, Moher D, Hayes RJ. “Allocation concealment”: the evolution and adoption of a methodological term. J R Soc Med. 2018;111(6):216-224. doi:10.1177/0141076818776604.
      Alam N, Oskam E, Stassen PM, et al. Prehospital antibiotics in the ambulance for sepsis: a multicentre, open label, randomised trial. Lancet Respir Med. 2018;6(1):40-50. doi:10.1016/S2213-2600(17)30469-1.
    • Contributed Indexing:
      Keywords: allocation concealment; blinding of interventions; clinical trials; evidence-based medicine; randomization; risk of bias
    • Publication Date:
      Date Created: 20220406 Date Completed: 20221118 Latest Revision: 20230310
    • Publication Date:
      20240105
    • Accession Number:
      10.1111/jep.13682
    • Accession Number:
      35384156