Null IFNAR1 and IFNAR2 alleles are surprisingly common in the Pacific and Arctic.

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  • Author(s): Meyts I;Meyts I
  • Source:
    The Journal of experimental medicine [J Exp Med] 2022 Jun 06; Vol. 219 (6). Date of Electronic Publication: 2022 Apr 29.
  • Publication Type:
    Journal Article; Research Support, Non-U.S. Gov't; Comment
  • Language:
    English
  • Additional Information
    • Source:
      Publisher: Rockefeller University Press Country of Publication: United States NLM ID: 2985109R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1540-9538 (Electronic) Linking ISSN: 00221007 NLM ISO Abbreviation: J Exp Med Subsets: MEDLINE
    • Publication Information:
      Original Publication: New York, NY : Rockefeller University Press
    • Subject Terms:
      Receptor, Interferon alpha-beta*/genetics; Alleles ; COVID-19/genetics ; COVID-19/immunology ; Humans ; Influenza, Human/genetics ; Influenza, Human/immunology ; Inuit ; Polynesia
    • Abstract:
      In this issue of JEM, Bastard et al. (2022. J. Exp. Med.https://doi.org/10.1084/jem.20220028) show that a loss-of-function IFNAR1 allele is common in western Polynesians, while Duncan et al. (2022. J. Exp. Med.https://doi.org/10.1084/jem.20212427) report that a loss-of-function IFNAR2 allele is common in Inuits. Homozygotes lack type I IFN immunity but are selectively vulnerable to influenza, COVID-19 pneumonia, and complications of live-attenuated viral vaccines.
      (© 2022 Meyts.)
    • Comments:
      Comment on: J Exp Med. 2022 Jun 6;219(6):. (PMID: 35442417)
    • References:
      Cell. 2019 Mar 21;177(1):184-199. (PMID: 30901539)
      J Clin Immunol. 2022 Jan;42(1):19-24. (PMID: 34713375)
      J Exp Med. 2022 Apr 4;219(4):. (PMID: 35319722)
    • Grant Information:
      Fonds Wetenschappelijk Onderzoek; International ERC_ European Research Council
    • Accession Number:
      0 (IFNAR1 protein, human)
      0 (IFNAR2 protein, human)
      156986-95-7 (Receptor, Interferon alpha-beta)
    • Publication Date:
      Date Created: 20220429 Date Completed: 20220503 Latest Revision: 20240328
    • Publication Date:
      20240329
    • Accession Number:
      PMC9070088
    • Accession Number:
      10.1084/jem.20220491
    • Accession Number:
      35486090