Research Progress of Totipotent Stem Cells.

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  • Author(s): Cai J;Cai J; Chen H; Chen H; Xie S; Xie S; Hu Z; Hu Z; Bai Y; Bai Y
  • Source:
    Stem cells and development [Stem Cells Dev] 2022 Jul; Vol. 31 (13-14), pp. 335-345. Date of Electronic Publication: 2022 Jun 23.
  • Publication Type:
    Journal Article; Review; Research Support, Non-U.S. Gov't
  • Language:
    English
  • Additional Information
    • Source:
      Publisher: Mary Ann Liebert, Inc Country of Publication: United States NLM ID: 101197107 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1557-8534 (Electronic) Linking ISSN: 15473287 NLM ISO Abbreviation: Stem Cells Dev Subsets: MEDLINE
    • Publication Information:
      Original Publication: Larchmont, NY : Mary Ann Liebert, Inc., c2004-
    • Subject Terms:
      Induced Pluripotent Stem Cells* ; Totipotent Stem Cells*; Animals ; Blastocyst ; Cell Differentiation ; Mammals
    • Abstract:
      Totipotent stem cells (TSCs), can develop into complete organisms, are used in biological fields such as regenerative medicine, mammalian breeding, and conservation. However, it is difficult to maintain the developmental totipotency and self-renewal capacity of cells cultured from early-stage embryos, which becomes a key factor limiting the research of TSCs. Fortunately, a breakthrough in the study of induced pluripotent stem cells returning to their totipotent state has been made, resulting in the establishment of multiple TSCs and igniting a new wave of stem cell research. Furthermore, the blastocyst-like structures can be generated by the established TSCs, which lays a foundation for synthetic embryos in vitro. In this review, we summarize the totipotent stage of early embryos, the establishment and cultivation of TSCs, and the developmental ability exploration of TSCs to promote further research of TSCs.
    • Contributed Indexing:
      Keywords: blastomeres; expanded potential stem cells; extended pluripotent stem cells; molecular mechanisms; totipotent blastomere-like cells; totipotent stem cells; zygote
    • Publication Date:
      Date Created: 20220503 Date Completed: 20220708 Latest Revision: 20220818
    • Publication Date:
      20240104
    • Accession Number:
      10.1089/scd.2022.0061
    • Accession Number:
      35502477