Current insights into the bone marrow niche: From biology in vivo to bioengineering ex vivo.

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  • Additional Information
    • Source:
      Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 8100316 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-5905 (Electronic) Linking ISSN: 01429612 NLM ISO Abbreviation: Biomaterials Subsets: MEDLINE
    • Publication Information:
      Publication: <1995-> : Amsterdam : Elsevier Science
      Original Publication: [Guilford, England] : IPC Science and Technology Press, 1980-
    • Subject Terms:
    • Abstract:
      Hematopoietic stem cells (HSCs) are fundamental to the generation of the body's blood and immune cells. They reside primarily within the bone marrow (BM) niche microenvironment, which provides signals responsible for the regulation of HSC activities. While our understanding of these signalling mechanisms continues to improve, our ability to recapitulate them in vitro to harness the clinical potential of the HSC populations is still lacking. Recent studies have applied novel engineering techniques combined with traditional in vitro work to establish ex vivo BM niche models. These models exhibit promising potential for research and clinical applications. In this review, BM niche factors that regulate the HSCs in vivo are discussed and their applications in the engineering of BM biomaterial-based platforms are considered. Many questions remain regarding the heterogeneity of niche components and the interactions of HSCs with their microenvironment. A greater understanding of the niche would help to elucidate these remaining questions, leading to the development of novel therapeutic tools.
      (Copyright © 2022 The Authors. Published by Elsevier Ltd.. All rights reserved.)
    • Grant Information:
      BB/N018419/1 United Kingdom BB_ Biotechnology and Biological Sciences Research Council
    • Contributed Indexing:
      Keywords: Biomaterials; Bone marrow niche; Hematopoietic stem cells; Niche engineering
    • Publication Date:
      Date Created: 20220517 Date Completed: 20220614 Latest Revision: 20220706
    • Publication Date:
      20240105
    • Accession Number:
      10.1016/j.biomaterials.2022.121568
    • Accession Number:
      35580474