The correlation between serum total alkaline phosphatase and bone mineral density in young adults.

Item request has been placed! ×
Item request cannot be made. ×
loading   Processing Request
Read Online Read More Add to Saved list
  • Author(s): Shu J;Shu J; Tan A; Tan A; Li Y; Li Y; Huang H; Huang H; Yang J; Yang J
  • Source:
    BMC musculoskeletal disorders [BMC Musculoskelet Disord] 2022 May 18; Vol. 23 (1), pp. 467. Date of Electronic Publication: 2022 May 18.
  • Publication Type:
    Journal Article
  • Language:
    English
  • Additional Information
    • Source:
      Publisher: BioMed Central Country of Publication: England NLM ID: 100968565 Publication Model: Electronic Cited Medium: Internet ISSN: 1471-2474 (Electronic) Linking ISSN: 14712474 NLM ISO Abbreviation: BMC Musculoskelet Disord Subsets: MEDLINE
    • Publication Information:
      Original Publication: London : BioMed Central, [2000-
    • Subject Terms:
      Alkaline Phosphatase*/blood ; Bone Density*; Absorptiometry, Photon ; Adult ; Age Factors ; Cross-Sectional Studies ; Female ; Humans ; Lumbar Vertebrae/diagnostic imaging ; Male ; Nutrition Surveys ; Young Adult
    • Abstract:
      Background: Elevated total alkaline phosphatase (T-ALP) levels are usually indicative of enhanced osteoblastic activity and bone conversion status and are thus considered as a key factor needed for fresh bone mineralization and synthesis. To date, there is no consistent conclusion on the association between the serum T-ALP levels and bone mineral density (BMD). Therefore, the present study focused on exploring the association of serum T-ALP with lumbar BMD among young adults.
      Methods: The present cross-sectional study included 6,331 subjects included in the National Health and Nutrition Examination Survey (NHANES) during 2011-2016. The participants aged 20-40 years included 3,349 males and 2,982 females. Serum T-ALP was our main variable, lumbar BMD was our outcome variable, and additional variables were the possible impact modifiers. The relations were analysed by the trend study, weighted multiple linear regression models, smooth curve fitting, and stratified analyses.
      Results: In a completely corrected multiple regression model, a negative association between serum T-ALP and lumbar BMD was discovered (β = -0.0007, 95% CI: -0.0009- -0.0005, P < 0.000001). After converting the continuous variable serum T-ALP into the categorical one, the significant negative association was still observed (P < 0.001), and in the subgroup and smooth curve fitting analyses, this negative correlation remained significant, too.
      Conclusions: Our study results indicated that serum T-ALP was negatively associated with lumbar BMD among young adults. Serum T-ALP measurement in the near future might become an effective biomarker to diagnose and treat osteoporosis on time.
      (© 2022. The Author(s).)
    • References:
      Scientifica (Cairo). 2020 Jul 12;2020:7075815. (PMID: 32765925)
      J Clin Lab Anal. 2020 Apr;34(4):e23112. (PMID: 31733013)
      Clin Orthop Relat Res. 2000 Mar;(372):139-50. (PMID: 10738423)
      Chem Biol Drug Des. 2020 Apr;95(4):451-459. (PMID: 31883507)
      Int J Endocrinol. 2020 Jun 29;2020:3082318. (PMID: 32676109)
      J Atheroscler Thromb. 2022 Jun 1;29(6):923-936. (PMID: 34108341)
      Osteoporos Int. 2004 Dec;15(12):981-91. (PMID: 15570414)
      Pak J Med Sci. 2021 Mar-Apr;37(2):384-388. (PMID: 33679918)
      Aging Clin Exp Res. 2019 Jun;31(6):889-895. (PMID: 31054116)
      Lancet. 2007 Oct 20;370(9596):1453-7. (PMID: 18064739)
      J Bone Miner Res. 1995 Jun;10(6):843-8. (PMID: 7572306)
      Tunis Med. 2014 May;92(5):304-10. (PMID: 25504382)
      Endocrinol Metab Clin North Am. 2012 Sep;41(3):475-86. (PMID: 22877425)
      Pak J Med Sci. 2019;35(3):749-753. (PMID: 31258588)
      Aging Clin Exp Res. 2021 Mar;33(3):603-609. (PMID: 32363431)
      Curr Opin Endocrinol Diabetes Obes. 2018 Dec;25(6):366-372. (PMID: 30299435)
      Tzu Chi Med J. 2019 Sep 12;32(4):367-372. (PMID: 33163383)
      Vital Health Stat 2. 2020 Apr;(184):1-35. (PMID: 33663649)
      Endocr Metab Immune Disord Drug Targets. 2019;19(3):259-273. (PMID: 30387405)
      Exp Ther Med. 2020 Feb;19(2):1432-1438. (PMID: 32010319)
      J Obes. 2021 Nov 9;2021:5325813. (PMID: 34796028)
      Osteoporos Int. 2007 Nov;18(11):1451-61. (PMID: 17566813)
      BMC Musculoskelet Disord. 2019 Apr 11;20(1):164. (PMID: 30971232)
      Eur J Rheumatol. 2017 Mar;4(1):46-56. (PMID: 28293453)
      J Orthop Surg Res. 2019 Dec 21;14(1):458. (PMID: 31864386)
      J Bone Metab. 2019 Feb;26(1):19-24. (PMID: 30899720)
      Vital Health Stat 2. 2018 Jan;(177):1-26. (PMID: 29775431)
      Eur J Clin Invest. 2021 Aug;51(8):e13560. (PMID: 33846986)
      J Spinal Cord Med. 2021 Dec 22;:1-14. (PMID: 34935593)
      Med Phys. 2011 Sep;38(9):5003-11. (PMID: 21978044)
    • Contributed Indexing:
      Keywords: Bone mineral density; Cross-sectional study; NHANES; Serum total alkaline phosphatase
    • Accession Number:
      EC 3.1.3.1 (Alkaline Phosphatase)
    • Publication Date:
      Date Created: 20220518 Date Completed: 20220520 Latest Revision: 20220716
    • Publication Date:
      20240105
    • Accession Number:
      PMC9118774
    • Accession Number:
      10.1186/s12891-022-05438-y
    • Accession Number:
      35585578