White matter integrity in adolescent irritability: A preliminary study.

Publisher: Elsevier Country of Publication: Netherlands NLM ID: 101723001 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-7506 (Electronic) Linking ISSN: 09254927 NLM ISO Abbreviation: Psychiatry Res Neuroimaging Subsets: MEDLINE

Original Publication: Amsterdam : Elsevier

White Matter*/diagnostic imaging; Adolescent ; Diffusion Tensor Imaging ; Humans ; Nerve Net ; Neural Pathways

Irritability is a prevalent, impairing transdiagnostic symptom, especially during adolescence, yet little is known about irritability's neural mechanisms. A few studies examined the integrity of white matter tracts that facilitate neural communication in irritability, but only with extreme, disorder-related symptom presentations. In this preliminary study, we used a group connectometry approach to identify white matter tracts correlated with transdiagnostic irritability in a community/clinic-based sample of 35 adolescents (mean age = 14 years, SD = 2.0). We found positive and negative associations with irritability in local white matter tract bundles including sections of the longitudinal fasciculus; frontoparietal, parolfactory, and parahippocampal cingulum; corticostriatal and thalamocortical radiations; and vertical occipital fasciculus. Our findings support functional neuroimaging studies that implicate widespread neural pathways, particularly emotion and reward networks, in irritability. Our findings of positive and negative associations reveal a complex picture of what is "good" white matter connectivity. By characterizing irritability's neural underpinnings, targeted interventions may be developed.
(Copyright © 2022. Published by Elsevier B.V.)

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UL1 TR001442 United States TR NCATS NIH HHS

Keywords: Adolescence; Connectometry; Diffusion weighted; Irritability; White matter

Date Created: 20220531 Date Completed: 20220628 Latest Revision: 20230802

20240104

PMC9676048

10.1016/j.pscychresns.2022.111491

35635933