Association of Nucleostemin Polymorphisms with Chronic Hepatitis B Virus Infection in Chinese Han Population.

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  • Additional Information
    • Source:
      Publisher: Mary Ann Liebert, Inc Country of Publication: United States NLM ID: 101494210 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1945-0257 (Electronic) Linking ISSN: 19450257 NLM ISO Abbreviation: Genet Test Mol Biomarkers Subsets: MEDLINE
    • Publication Information:
      Original Publication: New Rochelle, NY : Mary Ann Liebert, Inc.
    • Subject Terms:
      GTP-Binding Proteins*/genetics ; Hepatitis B, Chronic*/genetics ; Nuclear Proteins*/genetics; Asian People/genetics ; China ; Female ; Haplotypes ; Humans ; Male ; Polymorphism, Single Nucleotide
    • Abstract:
      Background: Chronic hepatitis B virus infection (CHB) is a common infectious disease that poses a global economic and health burden due to its high morbidity and mortality. Studies have demonstrated that host genetic factors play critical roles in the susceptibility and outcome of CHB. Aims: In this study, we aimed to assess the potential role of genetic variants of the nucleostemin ( NS ) gene with respect to CHB susceptibility. Materials and Methods: Four single nucleotide polymorphisms (SNPs) in the NS gene were genotyped in 446 patients with CHB and 399 healthy controls all of Chinese Han origin using the polymerase chain reaction-ligation detection reaction method. Results: The results showed that the three SNPs, rs3733039, rs1866268, and rs11177, were significantly associated with CHB. After a Bonferroni correction, the positive association of the rs3733039 SNP with CHB remained significant. Further analyses based on gender demonstrated that these SNPs are associated with CHB in both the female and male subgroups. After correction for multiple comparisons, all three SNPs in the female group were associated with CHB, whereas only the rs1866268 SNP in the male group was associated with CHB. Haplotype analysis showed that the C-C-G and T-T-T haplotypes in the block consisting of rs3733039-rs1866268-rs11177 were significantly associated with CHB. Conclusion: Our study demonstrated a genetic association between SNPs in the NS gene and the risk of CHB in the Chinese Han population for the first time. Thus, variations in the NS gene might serve as potential genetic biomarkers of CHB.
    • Comments:
      Comment in: Genet Test Mol Biomarkers. 2022 May;26(5):251-252. (PMID: 35638912)
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    • Contributed Indexing:
      Keywords: association; chronic hepatitis B virus infection; nucleostemin; single nucleotide polymorphisms
    • Accession Number:
      0 (GNL3 protein, human)
      0 (Nuclear Proteins)
      EC 3.6.1.- (GTP-Binding Proteins)
    • Publication Date:
      Date Created: 20220531 Date Completed: 20220602 Latest Revision: 20230502
    • Publication Date:
      20240104
    • Accession Number:
      PMC9150128
    • Accession Number:
      10.1089/gtmb.2021.0181
    • Accession Number:
      35638911