Common hematological parameters reference intervals for apparently healthy pregnant and non-pregnant women of South Wollo Zone, Amhara Regional State, Northeast Ethiopia.

Item request has been placed! ×
Item request cannot be made. ×
loading   Processing Request
Read Online Read More Add to Saved list
  • Additional Information
    • Source:
      Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE
    • Publication Information:
      Original Publication: San Francisco, CA : Public Library of Science
    • Subject Terms:
      Cross-Sectional Studies*; Blood Cell Count ; Ethiopia ; Female ; Humans ; Leukocyte Count ; Pregnancy ; Reference Values
    • Abstract:
      Background: Hematological reference intervals (RIs) are affected by inherent variables like age, sex, genetic background, environment, diet and certain circumstances such as pregnancy signifying the need for population specific values. This study was designed to establish RIs for common hematological parameters of apparently healthy pregnant and non-pregnant women from Northeast Ethiopia.
      Method: This community based cross-sectional study recruited 600 pregnant and non-pregnant women in South Wollo Zone, Northeast Ethiopia from June to August 2019. Complete blood count was performed for eligible participants using Mindary BC-3000 plus hematology analyzer. The mean, median, and 2.5th and 97.5th percentile reference limits with 90% CI were determined using SPSS version 23.
      Result: The established selected 2.5th-97.5th percentiles RIs for pregnant women were: WBC: 4.0-13.2x109/L; RBC: 3.45-4.67x1012/L; Hgb: 10.1-13.7g/dL; HCT: 33.5-46.5%; MCV: 85-104fL; MCH: 27.5-33.0pg; MCHC: 30.3-33.7g/dL and Platelet count: 132-373x109/L. The respective values for non-pregnant women were 3.6-10.3; 4.44-5.01; 12.4-14.3; 38.4-50.1; 86-102; 27.1-32.4, 30.4-34.1, 173-456. A statistically significant difference between pregnant and non-pregnant women was noted in all hematological parameters except MCHC. The mean and median value of WBC count, MCV, MPV and PDW increased, whereas mean values of HCT and Platelet count decreased as gestational period advances.
      Conclusion: The observed difference from other studies signify the necessity for using trimester specific RIs and separate RI for pregnant and non-pregnant women. Thus, we recommend the health facilities in the study area to utilize the currently established RIs for pregnant and non-pregnant women for better care.
      Competing Interests: The authors have declared that no competing interests exist.
    • References:
      Clin Pract. 2017 Jan 11;7(1):888. (PMID: 28243426)
      Indian J Hematol Blood Transfus. 2012 Sep;28(3):144-6. (PMID: 23997449)
      BMC Res Notes. 2018 Jan 22;11(1):55. (PMID: 29357920)
      EJIFCC. 2008 Oct 16;19(2):137-41. (PMID: 27683308)
      Pediatr Infect Dis J. 2001 Apr;20(4):397-403. (PMID: 11332664)
      Int J Womens Health. 2013 May 03;5:227-32. (PMID: 23662089)
      Clin Chim Acta. 2003 Aug;334(1-2):5-23. (PMID: 12867273)
      Rev Med Interne. 2012 Aug;33(8):446-52. (PMID: 22742709)
      Clin Biochem Rev. 2008 Aug;29 Suppl 1:S93-7. (PMID: 18852866)
      Clin Chem Lab Med. 2018 May 24;56(6):973-979. (PMID: 29303769)
      Int J Womens Health. 2017 Mar 03;9:145-150. (PMID: 28424562)
      PLoS One. 2017 Apr 11;12(4):e0175546. (PMID: 28399133)
      Ethiop J Health Sci. 2017 Nov;27(6):641-650. (PMID: 29487473)
      J Obstet Gynaecol. 2010 May;30(4):357-61. (PMID: 20455717)
      Eur J Haematol. 2007 Jul;79(1):39-46. (PMID: 17598837)
      Pan Afr Med J. 2018 Apr 09;29:205. (PMID: 30100959)
      EJIFCC. 2018 Apr 30;29(1):48-54. (PMID: 29765286)
      J Blood Med. 2017 Aug 28;8:123-130. (PMID: 28919829)
      PLoS One. 2013;8(1):e54289. (PMID: 23382888)
      Ultrasound Med Biol. 2006 Dec;32(12):1827-31. (PMID: 17169694)
      Korean J Hematol. 2012 Jun;47(2):136-41. (PMID: 22783361)
      PLoS One. 2021 Feb 16;16(2):e0244314. (PMID: 33591978)
      Pan Afr Med J. 2018 Mar 23;29:169. (PMID: 30050633)
      Malar J. 2013 Mar 04;12:86. (PMID: 23496910)
      PLoS One. 2014 May 15;9(5):e93919. (PMID: 24832127)
      Trop Med Int Health. 2018 Jul;23(7):765-773. (PMID: 29752840)
      Clin Chim Acta. 2022 Feb 15;527:56-60. (PMID: 35038434)
      Vaccine. 2003 Jul 28;21(24):3352-7. (PMID: 12850338)
      J Perianesth Nurs. 2003 Apr;18(2):96-114; quiz 115-7. (PMID: 12710004)
      Eur J Haematol. 2003 Jul;71(1):44-50. (PMID: 12801298)
      EJIFCC. 2008 Oct 16;19(2):95-105. (PMID: 27683304)
      Cancer Epidemiol Biomarkers Prev. 2007 Sep;16(9):1720-3. (PMID: 17855687)
      EBioMedicine. 2021 Dec;74:103715. (PMID: 34826802)
      PLoS One. 2008;3(12):e3919. (PMID: 19079547)
      Clin Pharmacokinet. 2012 Jun 1;51(6):365-96. (PMID: 22515555)
      J Clin Lab Anal. 2015 Jan;29(1):21-7. (PMID: 24390860)
      J Clin Lab Anal. 2017 Nov;31(6):. (PMID: 28105762)
      Obstet Gynecol. 2009 Dec;114(6):1326-1331. (PMID: 19935037)
    • Publication Date:
      Date Created: 20220715 Date Completed: 20220719 Latest Revision: 20220725
    • Publication Date:
      20240104
    • Accession Number:
      PMC9286272
    • Accession Number:
      10.1371/journal.pone.0270685
    • Accession Number:
      35839211