Menu
×
Main Library
9 a.m. - 8 p.m.
Phone: (843) 805-6930
West Ashley Library
9 a.m. - 7 p.m.
Phone: (843) 766-6635
Folly Beach Library
Closed for renovations
Phone: (843) 588-2001
John L. Dart Library
9 a.m. - 7 p.m.
Phone: (843) 722-7550
St. Paul's/Hollywood Library
9 a.m. - 8 p.m.
Phone: (843) 889-3300
Mt. Pleasant Library
9 a.m. – 8 p.m.
Phone: (843) 849-6161
Dorchester Road Library
9 a.m. - 8 p.m.
Phone: (843) 552-6466
Edgar Allan Poe/Sullivan's Island Library
9 a.m. - 1 p.m.
Phone: (843) 883-3914
John's Island Library
9 a.m. - 8 p.m.
Phone: (843) 559-1945
McClellanville Library
Closed for renovations
Phone: (843) 887-3699
Edisto Library
2 p.m. - 6 p.m.
Phone: (843) 869-2355
Wando Mount Pleasant Library
9 a.m. - 8 p.m.
Phone: (843) 805-6888
Otranto Road Library
9 a.m. - 8 p.m.
Phone: (843) 572-4094
Hurd/St. Andrews Library
Closed (Toddler Storytime)
Phone: (843) 766-2546
Baxter-Patrick James Island
9 a.m. - 8 p.m.
Phone: (843) 795-6679
Bees Ferry West Ashley Library
9 a.m. - 8 p.m.
Phone: (843) 805-6892
Village Library
9 a.m. - 1 p.m.
Phone: (843) 884-9741
Keith Summey North Charleston Library
9 a.m. – 8 p.m.
Phone: (843) 744-2489
Mobile Library
9 a.m. - 5 p.m.
Phone: (843) 805-6909
Today's Hours
Main Library
9 a.m. - 8 p.m.
Phone: (843) 805-6930
West Ashley Library
9 a.m. - 7 p.m.
Phone: (843) 766-6635
Folly Beach Library
Closed for renovations
Phone: (843) 588-2001
John L. Dart Library
9 a.m. - 7 p.m.
Phone: (843) 722-7550
St. Paul's/Hollywood Library
9 a.m. - 8 p.m.
Phone: (843) 889-3300
Mt. Pleasant Library
9 a.m. – 8 p.m.
Phone: (843) 849-6161
Dorchester Road Library
9 a.m. - 8 p.m.
Phone: (843) 552-6466
Edgar Allan Poe/Sullivan's Island Library
9 a.m. - 1 p.m.
Phone: (843) 883-3914
John's Island Library
9 a.m. - 8 p.m.
Phone: (843) 559-1945
McClellanville Library
Closed for renovations
Phone: (843) 887-3699
Edisto Library
2 p.m. - 6 p.m.
Phone: (843) 869-2355
Wando Mount Pleasant Library
9 a.m. - 8 p.m.
Phone: (843) 805-6888
Otranto Road Library
9 a.m. - 8 p.m.
Phone: (843) 572-4094
Hurd/St. Andrews Library
Closed (Toddler Storytime)
Phone: (843) 766-2546
Baxter-Patrick James Island
9 a.m. - 8 p.m.
Phone: (843) 795-6679
Bees Ferry West Ashley Library
9 a.m. - 8 p.m.
Phone: (843) 805-6892
Village Library
9 a.m. - 1 p.m.
Phone: (843) 884-9741
Keith Summey North Charleston Library
9 a.m. – 8 p.m.
Phone: (843) 744-2489
Mobile Library
9 a.m. - 5 p.m.
Phone: (843) 805-6909
Patron Login
menu
Item request has been placed!
×
Item request cannot be made.
×
Processing Request
Rare genetic variants explain missing heritability in smoking.
Item request has been placed!
×
Item request cannot be made.
×
Processing Request
- Author(s): Jang SK;Jang SK; Evans L; Evans L; Evans L; Fialkowski A; Fialkowski A; Arnett DK; Arnett DK; Ashley-Koch AE; Ashley-Koch AE; Barnes KC; Barnes KC; Becker DM; Becker DM; Bis JC; Bis JC; Blangero J; Blangero J; Bleecker ER; Bleecker ER; Boorgula MP; Boorgula MP; Bowden DW; Bowden DW; Brody JA; Brody JA; Cade BE; Cade BE; Jenkins BWC; Jenkins BWC; Carson AP; Carson AP; Chavan S; Chavan S; Cupples LA; Cupples LA; Custer B; Custer B; Damrauer SM; Damrauer SM; Damrauer SM; David SP; David SP; David SP; de Andrade M; de Andrade M; Dinardo CL; Dinardo CL; Fingerlin TE; Fingerlin TE; Fingerlin TE; Fornage M; Fornage M; Freedman BI; Freedman BI; Garrett ME; Garrett ME; Gharib SA; Gharib SA; Gharib SA; Glahn DC; Glahn DC; Haessler J; Haessler J; Heckbert SR; Heckbert SR; Heckbert SR; Hokanson JE; Hokanson JE; Hou L; Hou L; Hwang SJ; Hwang SJ; Hyman MC; Hyman MC; Judy R; Judy R; Justice AE; Justice AE; Kaplan RC; Kaplan RC; Kaplan RC; Kardia SLR; Kardia SLR; Kelly S; Kelly S; Kim W; Kim W; Kooperberg C; Kooperberg C; Levy D; Levy D; Levy D; Lloyd-Jones DM; Lloyd-Jones DM; Loos RJF; Loos RJF; Loos RJF; Manichaikul AW; Manichaikul AW; Gladwin MT; Gladwin MT; Martin LW; Martin LW; Nouraie M; Nouraie M; Melander O; Melander O; Melander O; Meyers DA; Meyers DA; Montgomery CG; Montgomery CG; North KE; North KE; Oelsner EC; Oelsner EC; Palmer ND; Palmer ND; Payton M; Payton M; Peljto AL; Peljto AL; Peyser PA; Peyser PA; Preuss M; Preuss M; Preuss M; Psaty BM; Psaty BM; Qiao D; Qiao D; Rader DJ; Rader DJ; Rader DJ; Rafaels N; Rafaels N; Redline S; Redline S; Reed RM; Reed RM; Reiner AP; Reiner AP; Rich SS; Rich SS; Rotter JI; Rotter JI; Schwartz DA; Schwartz DA; Schwartz DA; Shadyab AH; Shadyab AH; Silverman EK; Silverman EK; Smith NL; Smith NL; Smith NL; Smith JG; Smith JG; Smith JG; Smith AV; Smith AV; Smith JA; Smith JA; Tang W; Tang W; Taylor KD; Taylor KD; Telen MJ; Telen MJ; Vasan RS; Vasan RS; Vasan RS; Gordeuk VR; Gordeuk VR; Wang Z; Wang Z; Wang Z; Wiggins KL; Wiggins KL; Yanek LR; Yanek LR; Yang IV; Yang IV; Young KA; Young KA; Young KL; Young KL; Zhang Y; Zhang Y; Liu DJ; Liu DJ; Keller MC; Keller MC; Vrieze S; Vrieze S
- Source:
Nature human behaviour [Nat Hum Behav] 2022 Nov; Vol. 6 (11), pp. 1577-1586. Date of Electronic Publication: 2022 Aug 04.- Publication Type:
Journal Article; Research Support, N.I.H., Extramural- Language:
English - Source:
- Additional Information
- Source: Publisher: Springer Nature Publishing Country of Publication: England NLM ID: 101697750 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2397-3374 (Electronic) Linking ISSN: 23973374 NLM ISO Abbreviation: Nat Hum Behav Subsets: MEDLINE
- Publication Information: Original Publication: [London] : Springer Nature Publishing, [2017]-
- Subject Terms:
- Abstract: Common genetic variants explain less variation in complex phenotypes than inferred from family-based studies, and there is a debate on the source of this 'missing heritability'. We investigated the contribution of rare genetic variants to tobacco use with whole-genome sequences from up to 26,257 unrelated individuals of European ancestries and 11,743 individuals of African ancestries. Across four smoking traits, single-nucleotide-polymorphism-based heritability ([Formula: see text]) was estimated from 0.13 to 0.28 (s.e., 0.10-0.13) in European ancestries, with 35-74% of it attributable to rare variants with minor allele frequencies between 0.01% and 1%. These heritability estimates are 1.5-4 times higher than past estimates based on common variants alone and accounted for 60% to 100% of our pedigree-based estimates of narrow-sense heritability ([Formula: see text], 0.18-0.34). In the African ancestry samples, [Formula: see text] was estimated from 0.03 to 0.33 (s.e., 0.09-0.14) across the four smoking traits. These results suggest that rare variants are important contributors to the heritability of smoking.
(© 2022. The Author(s), under exclusive licence to Springer Nature Limited.) - References: Nat Genet. 2015 Jul;47(7):702-9. (PMID: 25985137)
Proc Natl Acad Sci U S A. 2012 Jan 24;109(4):1193-8. (PMID: 22223662)
Science. 2020 Mar 20;367(6484):. (PMID: 32193295)
Nature. 2021 Dec;600(7890):675-679. (PMID: 34887591)
RSF. 2018 Apr;4(4):137-149. (PMID: 30740524)
Behav Genet. 2006 Jul;36(4):553-66. (PMID: 16710775)
Nat Hum Behav. 2018 Dec;2(12):948-954. (PMID: 30988446)
Nature. 2009 Oct 8;461(7265):747-53. (PMID: 19812666)
Am J Hum Genet. 2013 Aug 8;93(2):278-88. (PMID: 23910464)
N Engl J Med. 2015 Feb 12;372(7):631-40. (PMID: 25671255)
Am J Hum Genet. 2011 Mar 11;88(3):294-305. (PMID: 21376301)
Nat Commun. 2020 Apr 15;11(1):1842. (PMID: 32296054)
Nicotine Tob Res. 2001 Aug;3(3):225-34. (PMID: 11506766)
Nat Rev Genet. 2010 Jun;11(6):446-50. (PMID: 20479774)
Nat Genet. 2015 Oct;47(10):1114-20. (PMID: 26323059)
Nat Genet. 2017 Feb;49(2):186-192. (PMID: 28067910)
Science. 2012 Jul 6;337(6090):100-4. (PMID: 22604722)
J Health Soc Behav. 2010 Mar;51(1):108-23. (PMID: 20420298)
Genet Epidemiol. 2021 Dec;45(8):821-829. (PMID: 34402542)
Nat Genet. 2016 Oct;48(10):1279-83. (PMID: 27548312)
Nat Hum Behav. 2021 Jun;5(6):686-694. (PMID: 33986517)
Nat Commun. 2020 Nov 3;11(1):5562. (PMID: 33144568)
Nat Commun. 2022 Feb 3;13(1):660. (PMID: 35115518)
Nat Commun. 2020 Nov 30;11(1):6130. (PMID: 33257650)
Addiction. 2013 Sep;108(9):1680-5. (PMID: 23668684)
Nat Commun. 2021 Sep 14;12(1):5420. (PMID: 34521848)
Nat Hum Behav. 2021 Dec;5(12):1717-1730. (PMID: 34211149)
Hum Mol Genet. 2018 Oct 15;27(20):3641-3649. (PMID: 30124842)
Bioinformatics. 2020 Jun 1;36(11):3439-3446. (PMID: 32196066)
Nature. 2016 Aug 4;536(7614):41-47. (PMID: 27398621)
Am J Hum Genet. 2016 Jan 7;98(1):127-48. (PMID: 26748516)
Philos Trans R Soc Lond B Biol Sci. 2005 Jul 29;360(1459):1411-25. (PMID: 16048784)
Science. 2019 Sep 27;365(6460):1396-1400. (PMID: 31604265)
Drug Alcohol Depend. 2015 Aug 1;153:221-8. (PMID: 26051161)
Nicotine Tob Res. 2018 Jul 9;20(8):923-930. (PMID: 29986103)
Nicotine Tob Res. 2017 Apr 01;19(4):401-409. (PMID: 27807125)
Mol Psychiatry. 2020 Oct;25(10):2392-2409. (PMID: 30617275)
Nature. 2014 Jul 24;511(7510):421-7. (PMID: 25056061)
BMC Public Health. 2011 May 14;11:316. (PMID: 21569578)
PLoS Genet. 2019 Jun 24;15(6):e1008222. (PMID: 31233496)
Ann Epidemiol. 2005 Jul;15(6):445-52. (PMID: 15967392)
Bioinformatics. 2018 May 1;34(9):1506-1513. (PMID: 29194474)
Science. 2012 May 11;336(6082):740-3. (PMID: 22582263)
Am J Hum Genet. 2011 Jan 7;88(1):76-82. (PMID: 21167468)
Am J Respir Crit Care Med. 2019 Jan 15;199(2):237-240. (PMID: 30215529)
Nat Genet. 2012 Feb 05;44(3):243-6. (PMID: 22306651)
Fly (Austin). 2012 Apr-Jun;6(2):80-92. (PMID: 22728672)
Lancet. 2017 May 13;389(10082):1885-1906. (PMID: 28390697)
Nat Genet. 2017 Oct;49(10):1421-1427. (PMID: 28892061)
Sci Rep. 2021 Sep 24;11(1):19015. (PMID: 34561511)
Nat Genet. 2019 Sep;51(9):1349-1355. (PMID: 31477931)
Nat Genet. 2020 Jul;52(7):680-691. (PMID: 32541925)
Lancet. 2002 Nov 2;360(9343):1347-60. (PMID: 12423980)
Nat Genet. 2022 Mar;54(3):263-273. (PMID: 35256806)
Nat Genet. 2018 May;50(5):737-745. (PMID: 29700474)
Nat Hum Behav. 2017 Oct;1(10):757-765. (PMID: 29051922)
Transl Psychiatry. 2020 Feb 24;10(1):74. (PMID: 32094344)
Am J Hum Genet. 2021 May 6;108(5):825-839. (PMID: 33836139)
Nat Genet. 2016 Nov;48(11):1443-1448. (PMID: 27694958)
Nat Hum Behav. 2019 Dec;3(12):1332-1342. (PMID: 31636407)
Heredity (Edinb). 2020 Jun;124(6):751-762. (PMID: 32273574)
Nat Rev Genet. 2012 Jan 18;13(2):135-45. (PMID: 22251874)
Mol Psychiatry. 2012 May;17(5):474-85. (PMID: 21670730)
Proc Natl Acad Sci U S A. 2010 Jan 26;107 Suppl 1:1752-6. (PMID: 20133822)
Addiction. 2021 Sep;116(9):2498-2508. (PMID: 33620764)
Nat Genet. 2010 Jul;42(7):565-9. (PMID: 20562875)
Addiction. 2004 Dec;99(12):1548-59. (PMID: 15585046)
Elife. 2020 Nov 17;9:. (PMID: 33200985)
Nature. 2021 Feb;590(7845):290-299. (PMID: 33568819)
PLoS Genet. 2013 May;9(5):e1003520. (PMID: 23737753)
Nat Genet. 2019 Feb;51(2):237-244. (PMID: 30643251)
Addiction. 2003 Jul;98(7):923-31. (PMID: 12814498) - Grant Information: HHSN268201800003I United States HL NHLBI NIH HHS; HHSN268201800005I United States HL NHLBI NIH HHS; HHSN268201800007I United States HL NHLBI NIH HHS; R01 HL119443 United States HL NHLBI NIH HHS; IK2 CX001780 United States CX CSRD VA; HHSN268201700001I United States HL NHLBI NIH HHS; R01 DA037904 United States DA NIDA NIH HHS; R01 HG011035 United States HG NHGRI NIH HHS; R01 AG058921 United States AG NIA NIH HHS; HHSN268201500014C United States HL NHLBI NIH HHS; HHSN268201500001I United States HL NHLBI NIH HHS; N01HC85081 United States HL NHLBI NIH HHS; R03 OD032630 United States OD NIH HHS; R01 EB015611 United States EB NIBIB NIH HHS; R01 HL153805 United States HL NHLBI NIH HHS; N01HC55222 United States HL NHLBI NIH HHS; R01 HL113338 United States HL NHLBI NIH HHS; HHSN268201800012I United States HB NHLBI NIH HHS; 75N92019D00031 United States HL NHLBI NIH HHS; N01HC85082 United States HL NHLBI NIH HHS; F32 HL085989 United States HL NHLBI NIH HHS; HHSN268201700005I United States HL NHLBI NIH HHS; R01 HL105756 United States HL NHLBI NIH HHS; R01 HL113323 United States HL NHLBI NIH HHS; HHSN268201700004I United States HL NHLBI NIH HHS; R35 HL135818 United States HL NHLBI NIH HHS; R01 HG008983 United States HG NHGRI NIH HHS; HHSN268201200036C United States HL NHLBI NIH HHS; HHSN268201800011I United States HB NHLBI NIH HHS; U01 HL089856 United States HL NHLBI NIH HHS; HHSN268201700003I United States HL NHLBI NIH HHS; HHSN268201800010I United States HB NHLBI NIH HHS; HHSN268200800007C United States HL NHLBI NIH HHS; 75N92021D00006 United States HL NHLBI NIH HHS; U01 HL054457 United States HL NHLBI NIH HHS; R01 DK071891 United States DK NIDDK NIH HHS; R01 HL085571 United States HL NHLBI NIH HHS; R01 MH100141 United States MH NIMH NIH HHS; HHSN268201700002I United States HL NHLBI NIH HHS; N01HC85080 United States HL NHLBI NIH HHS; HHSN268201800006I United States HL NHLBI NIH HHS; R01 NS058700 United States NS NINDS NIH HHS; R01 HL087660 United States HL NHLBI NIH HHS; HHSN268201800001C United States HL NHLBI NIH HHS; HHSN268201800013I United States MD NIMHD NIH HHS; U01 HL089897 United States HL NHLBI NIH HHS; HHSN268201100007I United States HL NHLBI NIH HHS; HHSN268201800004I United States HL NHLBI NIH HHS; R01 DA044283 United States DA NIDA NIH HHS; U01 HL054464 United States HL NHLBI NIH HHS; N01HC85086 United States HL NHLBI NIH HHS; N01HC85079 United States HL NHLBI NIH HHS
- Publication Date: Date Created: 20220804 Date Completed: 20221122 Latest Revision: 20240315
- Publication Date: 20240315
- Accession Number: PMC9985486
- Accession Number: 10.1038/s41562-022-01408-5
- Accession Number: 35927319
- Source:
Contact CCPL
Copyright 2022 Charleston County Public Library Powered By EBSCO Stacks 3.3.0 [350.3] | Staff Login
No Comments.