Interaction between microbiota and immunity and its implication in colorectal cancer.

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  • Additional Information
    • Source:
      Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101560960 Publication Model: eCollection Cited Medium: Internet ISSN: 1664-3224 (Electronic) Linking ISSN: 16643224 NLM ISO Abbreviation: Front Immunol Subsets: MEDLINE
    • Publication Information:
      Original Publication: [Lausanne : Frontiers Research Foundation]
    • Subject Terms:
    • Abstract:
      Colorectal cancer (CRC) is one of the leading causes of cancer-related death in the world. Besides genetic causes, colonic inflammation is one of the major risk factors for CRC development, which is synergistically regulated by multiple components, including innate and adaptive immune cells, cytokine signaling, and microbiota. The complex interaction between CRC and the gut microbiome has emerged as an important area of current CRC research. Metagenomic profiling has identified a number of prominent CRC-associated bacteria that are enriched in CRC patients, linking the microbiota composition to colitis and cancer development. Some microbiota species have been reported to promote colitis and CRC development in preclinical models, while a few others are identified as immune modulators to induce potent protective immunity against colitis and CRC. Mechanistically, microbiota regulates the activation of different immune cell populations, inflammation, and CRC via crosstalk between innate and adaptive immune signaling pathways, including nuclear factor kappa B (NF-κB), type I interferon, and inflammasome. In this review, we provide an overview of the potential interactions between gut microbiota and host immunity and how their crosstalk could synergistically regulate inflammation and CRC, thus highlighting the potential roles and mechanisms of gut microbiota in the development of microbiota-based therapies to prevent or alleviate colitis and CRC.
      Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
      (Copyright © 2022 Xing, Du, Duan, Nim, Chu, Wang and Wang.)
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    • Grant Information:
      R01 CA101795 United States CA NCI NIH HHS; R01 CA246547 United States CA NCI NIH HHS; U54 CA210181 United States CA NCI NIH HHS
    • Contributed Indexing:
      Keywords: adaptive immunity; colitis; colorectal cancer; immune signaling; immunotherapy; innate immunity; metabolites; microbiota
    • Publication Date:
      Date Created: 20220815 Date Completed: 20220816 Latest Revision: 20220825
    • Publication Date:
      20240104
    • Accession Number:
      PMC9373904
    • Accession Number:
      10.3389/fimmu.2022.963819
    • Accession Number:
      35967333