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Bayesian method application: Integrating mathematical modeling into clinical pharmacy through vancomycin therapeutic monitoring.
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- Author(s): Chen A;Chen A; Gupta A; Gupta A; Gupta A; Do DH; Do DH; Do DH; Nazer LH; Nazer LH
- Source:
Pharmacology research & perspectives [Pharmacol Res Perspect] 2022 Dec; Vol. 10 (6), pp. e01026.- Publication Type:
Journal Article; Review- Language:
English - Source:
- Additional Information
- Source: Publisher: John Wiley & Sons Ltd, British Pharmacological Society and American Society for Pharmacology and Experimental Therapeutics Country of Publication: United States NLM ID: 101626369 Publication Model: Print Cited Medium: Internet ISSN: 2052-1707 (Electronic) Linking ISSN: 20521707 NLM ISO Abbreviation: Pharmacol Res Perspect Subsets: MEDLINE
- Publication Information: Original Publication: [Hoboken, NJ] : John Wiley & Sons Ltd, British Pharmacological Society and American Society for Pharmacology and Experimental Therapeutics, [2013]-
- Subject Terms:
- Abstract: The most recent consensus guidelines for dosing and monitoring vancomycin recommended the use of area-under-the-curve with Bayesian estimation for therapeutic monitoring. As this is a modern concept in the practice of clinical pharmacy, the main objective of this review is to introduce the fundamentals of Bayesian estimation and its mathematical application as it relates to vancomycin therapeutic drug monitoring. In addition, we aim to identify pharmacokinetic (PK) software programs that incorporate Bayesian estimation for vancomycin dosing and to describe the PK models utilized in those software programs for the adult population. Twelve software programs that utilize Bayesian estimation were identified, which included: Adult and Pediatric Kinetics, Best Dose, ClinCalc, DoseMeRx, ID-ODS, InsightRx, MwPharm++, NextDose, PrecisePK, TDMx, Tucuxi, and VancoCalc. The software programs varied in the population PK models used as the Bayesian a priori. With the presence of various vancomycin Bayesian software programs, it is important to choose those that utilize PK models reflective of the specific patient population.
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Antimicrob Agents Chemother. 2017 Nov 22;61(12):. (PMID: 28923869) - Contributed Indexing: Keywords: Bayes theorem; pharmacokinetics; therapeutic drug monitoring; vancomycin
- Accession Number: 6Q205EH1VU (Vancomycin)
0 (Anti-Bacterial Agents) - Publication Date: Date Created: 20221118 Date Completed: 20221121 Latest Revision: 20230211
- Publication Date: 20240104
- Accession Number: PMC9672880
- Accession Number: 10.1002/prp2.1026
- Accession Number: 36398492
- Source:
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