Inverse relationship between HBV DNA levels and liver histopathological changes in immune-tolerant CHB patients.

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    • Source:
      Publisher: Blackwell Scientific Publications Country of Publication: England NLM ID: 9435672 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1365-2893 (Electronic) Linking ISSN: 13520504 NLM ISO Abbreviation: J Viral Hepat Subsets: MEDLINE
    • Publication Information:
      Original Publication: Oxford ; Boston : Blackwell Scientific Publications, 1994-
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    • Abstract:
      Limited data exist regarding the association between hepatitis B virus (HBV) DNA levels and liver histopathological changes in patients with chronic hepatitis B (CHB) during the immune tolerant (IT) phase. In this study, we retrospectively analysed liver biopsy results from 150 adult IT-CHB patients. The liver tissue necroinflammation and fibrosis were evaluated by the Scheuer scoring system. Multivariate logistic regression, smooth curve fitting, and segmented regression models were used to examine the association between HBV DNA levels and liver histopathological changes. A total of 26%, 30.67% and 42% of IT patients had significant necroinflammation (≥G2), significant fibrosis (≥S2) and significant histopathological changes (≥G2 and/or ≥S2), respectively. HBV DNA levels were independently and non-linear inversely associated with significant necroinflammation and histopathological changes in IT-CHB patients. Patients with HBV DNA levels <10 7  IU/mL had a higher risk of significant histopathological changes compared to those with levels >10 7  IU/mL. The findings were further confirmed by smooth curve fitting analyses, subgroup and sensitivity analyses. In segmented regression model analyses, the optimal DNA value for the lowest odds ratio of significant histopathological changes was 7.26 log10 IU/mL. A non-linear inverse association between HBV DNA levels and significant histopathological changes in IT-CHB patients. DNA 7.26 log10 IU/mL may serve as a potential cut-off point to define a 'true immune tolerant phase' with minimal liver histopathological changes.
      (© 2024 John Wiley & Sons Ltd.)
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    • Grant Information:
      This study was supported by the funds for the construction of key medical disciplines in Shenzhen No.SZXK076
    • Contributed Indexing:
      Keywords: HBV DNA; chronic hepatitis B; immune tolerant phase; liver biopsy
    • Accession Number:
      0 (DNA, Viral)
    • Publication Date:
      Date Created: 20240406 Date Completed: 20240611 Latest Revision: 20240611
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