A mathematical model for HIV dynamics with multiple infections: implications for immune escape.

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  • Author(s): Deng Q;Deng Q;Deng Q; Guo T; Guo T; Qiu Z; Qiu Z; Chen Y; Chen Y
  • Source:
    Journal of mathematical biology [J Math Biol] 2024 May 19; Vol. 89 (1), pp. 6. Date of Electronic Publication: 2024 May 19.
  • Publication Type:
    Journal Article
  • Language:
    English
  • Additional Information
    • Source:
      Publisher: Springer Verlag Country of Publication: Germany NLM ID: 7502105 Publication Model: Electronic Cited Medium: Internet ISSN: 1432-1416 (Electronic) Linking ISSN: 03036812 NLM ISO Abbreviation: J Math Biol Subsets: MEDLINE
    • Publication Information:
      Publication: Berlin : Springer Verlag
      Original Publication: Wien, New York, Springer-Verlag.
    • Subject Terms:
    • Abstract:
      Multiple infections enable the recombination of different strains, which may contribute to viral diversity. How multiple infections affect the competition dynamics between the two types of strains, the wild and the immune escape mutant, remains poorly understood. This study develops a novel mathematical model that includes the two strains, two modes of viral infection, and multiple infections. For the representative double-infection case, the reproductive numbers are derived and global stabilities of equilibria are obtained via the Lyapunov direct method and theory of limiting systems. Numerical simulations indicate similar viral dynamics regardless of multiplicities of infections though the competition between the two strains would be the fiercest in the case of quadruple infections. Through sensitivity analysis, we evaluate the effect of parameters on the set-point viral loads in the presence and absence of multiple infections. The model with multiple infections predict that there exists a threshold for cytotoxic T lymphocytes (CTLs) to minimize the overall viral load. Weak or strong CTLs immune response can result in high overall viral load. If the strength of CTLs maintains at an intermediate level, the fitness cost of the mutant is likely to have a significant impact on the evolutionary dynamics of mutant viruses. We further investigate how multiple infections alter the viral dynamics during the combination antiretroviral therapy (cART). The results show that viral loads may be underestimated during cART if multiple-infection is not taken into account.
      (© 2024. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.)
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    • Grant Information:
      202006840122 China Scholarship Council; CJ20220134 Changzhou Scientific and Technological Program grant; 22KJB110007 Natural Science Foundation of Jiangsu Higher Education; 12071217 National Natural Science Foundation of China; 12201077 National Natural Science Foundation of China; RGPIN-2019-05892 NSERC of Canada
    • Contributed Indexing:
      Keywords: Cytotoxic T lymphocyte; HIV; Immune escape; Multiple infections
    • Publication Date:
      Date Created: 20240519 Date Completed: 20240519 Latest Revision: 20240519
    • Publication Date:
      20240519
    • Accession Number:
      10.1007/s00285-024-02104-w
    • Accession Number:
      38762831