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West Ashley Library
9 a.m. - 7 p.m.
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Folly Beach Library
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9 a.m. - 7 p.m.
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St. Paul's/Hollywood Library
9 a.m. - 8 p.m.
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9 a.m. – 8 p.m.
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Wando Mount Pleasant Library
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Review Can zebrafish be used as a model to study the neurodevelopmental causes of autism?
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- Author(s): Tropepe, V.; Sive, H. L.
- Source:
Genes, Brain & Behavior; Oct2003, Vol. 2 Issue 5, p268-281, 14p- Subject Terms:
- Source:
- Additional Information
- Abstract: The zebrafish has proven to be an excellent model for analyzing issues of vertebrate development. In this review we ask whether the zebrafish is a viable model for analyzing the neurodevelopmental causes of autism. In developing an answer to this question three topics are considered. First, the general attributes of zebrafish as a model are discussed, including low cost maintenance, rapid life cycle and the multitude of techniques available. These techniques include large-scale genetic screens, targeted loss and gain of function methods, and embryological assays. Second, we consider the conservation of zebrafish and mammalian brain development, structure and function. Third, we discuss the impressive use of zebrafish as a model for human disease, and suggest several strategies by which zebrafish could be used to dissect the genetic basis for autism. We conclude that the zebrafish system could be used to make important contributions to understanding autistic disorders. [ABSTRACT FROM AUTHOR]
- Abstract: Copyright of Genes, Brain & Behavior is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Abstract:
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