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Multimodal imaging based on MRI and PET reveals [F]FLT PET as a specific and early indicator of treatment efficacy in a preclinical model of recurrent glioblastoma.
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- Author(s): Corroyer-Dulmont, Aurélien; Pérès, Elodie; Gérault, Aurélie; Savina, Ariel; Bouquet, Fanny; Divoux, Didier; Toutain, Jérôme; Ibazizène, Méziane; MacKenzie, Eric; Barré, Louisa; Bernaudin, Myriam; Petit, Edwige; Valable, Samuel
- Source:
European Journal of Nuclear Medicine & Molecular Imaging; Apr2016, Vol. 43 Issue 4, p682-694, 13p, 1 Color Photograph, 1 Diagram, 1 Chart, 4 Graphs- Subject Terms:
- Source:
- Additional Information
- Abstract: Purpose: The primary objective of this study was to compare the ability of PET and MRI biomarkers to predict treatment efficacy in a preclinical model of recurrent glioblastoma multiforme. Methods: MRI (anatomical, diffusion, vasculature and oxygenation) and PET ([F]FDG and [F]FLT) parameters were obtained 3 days after the end of treatment and compared with late tumour growth and survival. Results: Early after tumour recurrence, no effect of treatment with temozolomide combined with bevacizumab was observed on tumour volume as assessed by T2-W MRI. At later times, the treatment decreased tumour volume and increased survival. Interestingly, at the earlier time, temozolomide + bevacizumab decreased [F]FLT uptake, cerebral blood volume and oedema. [F]FLT uptake, oedema and cerebral blood volume were correlated with overall survival but [F]FLT uptake had the highest specificity and sensitivity for the early prediction of treatment efficacy. Conclusion: The present investigation in a preclinical model of glioblastoma recurrence underscores the importance of multimodal imaging in the assessment of oedema, tumour vascular status and cell proliferation. Finally, [F]FLT holds the greatest promise for the early assessment of treatment efficacy. These findings may translate clinically in that individualized treatment for recurrent glioma could be prescribed for patients selected after PET/MRI examinations. [ABSTRACT FROM AUTHOR]
- Abstract: Copyright of European Journal of Nuclear Medicine & Molecular Imaging is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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