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Phone: (843) 805-6930
West Ashley Library
9 a.m. – 7 p.m.
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John L. Dart Library
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St. Paul's/Hollywood Library
9 a.m. - 8 p.m.
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ICC-dementia (International Centenarian Consortium - dementia): an international consortium to determine the prevalence and incidence of dementia in centenarians across diverse ethnoracial and sociocultural groups.
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- Author(s): Brodaty, Henry; Woolf, Claudia; Andersen, Stacy; Barzilai, Nir; Brayne, Carol; Siu-Lan Cheung, Karen; Corrada, Maria M.; Crawford, John D.; Daly, Catriona; Gondo, Yasuyuki; Hagberg, Bo; Hirose, Nobuyoshi; Holstege, Henne; Kawas, Claudia; Kaye, Jeffrey; Kochan, Nicole A.; Bobo Hi-Po Lau; Lucca, Ugo; Marcon, Gabriella; Martin, Peter
- Source:
BMC Neurology; 4/21/2016, Vol. 16, p1-10, 10p, 2 Charts- Subject Terms:
DEMENTIA patients; CENTENARIANS; SOCIOCULTURAL factors; CULTURAL pluralism; DISEASES in older people; HEALTH; BRAIN physiology; COGNITION; COMPARATIVE studies; DEMENTIA; RESEARCH methodology; MEDICAL cooperation; RESEARCH; RESEARCH funding; EVALUATION research; RELATIVE medical risk; DISEASE incidence; DISEASE prevalence - Source:
- Additional Information
- Abstract:
Background: Considerable variability exists in international prevalence and incidence estimates of dementia. The accuracy of estimates of dementia in the oldest-old and the controversial question of whether dementia incidence and prevalence decline at very old age will be crucial for better understanding the dynamics between survival to extreme old age and the occurrence and risk for various types of dementia and comorbidities. International Centenarian Consortium - Dementia (ICC-Dementia) seeks to harmonise centenarian and near-centenarian studies internationally to describe the cognitive and functional profiles of exceptionally old individuals, and ascertain the trajectories of decline and thereby the age-standardised prevalence and incidence of dementia in this population. The primary goal of the ICC-Dementia is to establish a large and thorough heterogeneous sample that has the power to answer epidemiological questions that small, separate studies cannot. A secondary aim is to examine cohort-specific effects and differential survivorship into very old age. We hope to lay the foundation for further investigation into risk and protective factors for dementia and healthy exceptional brain ageing in centenarians across diverse ethnoracial and sociocultural groups.Methods: Studies focusing on individuals aged ≥95 years (approximately the oldest 1 percentile for men, oldest 5th percentile for women), with a minimum sample of 80 individuals, including assessment of cognition and functional status, are invited to participate. There are currently seventeen member or potential member studies from Asia, Europe, the Americas, and Oceania. Initial attempts at harmonising key variables are in progress.Discussion: General challenges facing large, international consortia like ICC-Dementia include timely and effective communication among member studies, ethical and practical issues relating to human subject studies and data sharing, and the challenges related to data harmonisation. A specific challenge for ICC-Dementia relates to the concept and definition of'abnormal' in this exceptional group of individuals who are rarely free of physical, sensory and/or cognitive impairments. [ABSTRACT FROM AUTHOR] - Abstract: Copyright of BMC Neurology is the property of BioMed Central and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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