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Comparative Behavioral Toxicity of the Selective Serotonin Reuptake Inhibitors.
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- Author(s): Sherwood, N.
- Source:
Human Psychopharmacology: Clinical & Experimental; Oct95 Supplement 3, Vol. 10, p159-162, 4p- Subject Terms:
- Source:
- Additional Information
- Abstract: The psychopharmacological profiles of several selective serotonin reuptake inhibitors (SSRIs) were compared and their behavioural toxicity contrasted both to placebo and the tricyclic antidepressants dothiepin and amitriptyline. On measures of central nervous system arousal (critical flicker fusion), psychomotor speed (choice reaction time). skilled performance (compensatory tracking) and subjective ratings of sedation (line analogue rating scales), the tricyclic compounds clearly impaired performance and led to higher ratings of sedation. While the SSRIs were generally clear of these gross effects, there were quantifiable differences between the compounds, seen mainly as an increase in central nervous system arousal. It remains to be established whether these minor differences have any clinical relevance. [ABSTRACT FROM AUTHOR]
- Abstract: Copyright of Human Psychopharmacology: Clinical & Experimental is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Abstract:
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