骨质疏松症患者骨密度与血清25 羟维生素D 的相关 性研究. (Chinese)

The study of the relationship between BMD and the serum level of 25-OH vitamin D in patients with osteoporosis. (English)

Objective To investigate the relationship between BMD and the serum level of 25-OH vitamin D in patients with osteoporosis． Methods A total of 397 participators were enrolled． BMD of the lumbar 1-4，the left femoral neck，and the left proximal femur was measured． Parathyroid hormone ( PTH) ，total collagen type I N-terminal propeptide ( P1NP) ，B collagen degradation products β-CTX，N end of osteocalcin ( N-MID) ，and the level of serum 25 hydroxy vitamin D ( 25-OHD) were examined． They were divided into 3 groups according to their BMD levels: no osteoporosis group ( n = 118) ，osteopenia group ( n = 153) ，and osteoporosis group ( n = 126 ) ． Ｒesults ( 1 ) BMD in the osteopenia group and osteoporosis group was significantly lower than that in the normal bone mass group ( P ＜ 0. 01) ，and it was significantly lower in the osteoporosis group than that in the osteopenia group ( P ＜ 0. 01) ． ( 2) 25-OHD，PTH，P1NP，β-CTX，and N-MID were significantly lower in the osteoporosis group than those in the normal bone mass ( P ＜ 0. 01) ． ( 3) There was no correlation between 25-OHD and BMD of the lumbar 1-4 and left femoral neck，and β-CTX ( P ＞ 0. 05) ． The correlation coefficient between 25-OHD and N-MID was 0. 193 ( P ＜ 0. 01) ． There was no significant difference of 25-OHD between the groups of different BMD ( P ＞ 0. 05) ． Conclusion The insufficient level of vitamin D and osteoporosis are popular in the elderly． The proportion of deficiency and serious deficiency of vitamin D is large，providing certain reference data for the prevention and treatment of osteoporosis． We should pay attention to strengthen the education and prevention． The direct correlation between 25-OHD and BMD is not found． [ABSTRACT FROM AUTHOR]

目的分析骨质疏松症患者骨密度与血清25 羟维生素D 的相关性。方法记录397 例50 ～ 97 岁患者的年龄，检测腰 椎1 ～ 4、左侧股骨颈、左侧股骨上端的骨密度( bone mineral density，BMD) ，检测骨质疏松4 项［甲状旁腺素( parathyroid hormone，PTH) 、总I 型胶原氨基端前肽( procollagen type 1 amino-terminal propeptide，P1NP) 、β 胶原降解产物( beta collagen degradation products，β-CTX) 、N 端骨钙素( N end of osteocalcin，N-MID) ］及血清25 羟维生素D［25-( OH) D］的水平，根据BMD 水平将受试者分为骨量正常组( n = 118) 、骨量低下组( n = 153) 和骨质疏松组( n = 126) 。结果( 1) 骨量低下组及骨质疏松 组的BMD 均明显低于正常骨量组( P ＜ 0. 01) ，骨质疏松组又明显低于骨量低下组( P ＜ 0. 01) ; ( 2) 骨质疏松组25-( OH) D、 PTH、P1NP、β-Crosslaps 及N-CTX 均明显低于正常骨量组( P ＜ 0. 01) ; ( 3) 25-( OH) D 与腰椎1 ～ 4、左侧股骨颈、左侧股骨上端 的BMD、PTH、P1NP、β-CTX 无相关性( P ＞ 0. 05) ， 25-( OH) D 与N-MID 的相关系数为0. 193( P ＜ 0. 01) 。不同骨密度组间的 25-( OH) D 差异无统计学意义( P ＞ 0. 05) 。结论老年人群普遍存在维生素D( vitamin D，VD) 水平不足的现象，而骨质疏松 症患者更为突出，其中VD 严重缺乏和缺乏所占比例较大，为骨质疏松症的防治提供一定的数据参考，应注意加强宣教及防 治。尚未发现25-( OH) D 与骨密度之间存在着直接相关关系。 [ABSTRACT FROM AUTHOR]

Copyright of Chinese Journal of Osteoporosis is the property of Chinese Journal of Osteoporosis and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)