骨钙素与认知功能障碍关系的研究进展. (Chinese)

Ｒesearch progress in the relationship between osteocalcin and cognitive decline. (English)

Osteocalcin ( OC) is a structural protein synthesized by osteoblasts，and it has been long regarded as a marker in regulating the bone metabolism． However，recent studies have discovered that OC is actually a hormone participating in the glucose and lipid metabolism as well as the synthesis of leptin and adiponectin，which may indirectly affect the cognitive function of the brain． The newest research has shown that OC plays a decisive role in brain development，neural structure，and behavioral patterns． Especially，animal experiments have shown that uncarboxylated osteocalcin ( uc OC) may cross the blood-brain barrier，act on the neurons in brain stem，midbrain and hippocampus，and finally improve the cognitive function． Studies on the relationship between OC and cognitive dysfunction can help to find a new way to explore the cognitive interventions [ABSTRACT FROM AUTHOR]

骨钙素( osteocalcin，OC) 是一种由成骨细胞合成的结构蛋白，既往OC 被视为调节骨代谢的标记物，近来研究证实OC 为一种内分泌激素，并参与糖脂代谢、瘦素及脂联素的合成，进而间接影响认知功能。最新研究表明OC 对大脑发育、神经结 构和行为功能具有决定性作用，有动物实验发现羧化不全骨钙素( uncarboxylated osteocalcin，uc OC) 可以穿过血脑屏障作用于 脑干、中脑、海马中神经元而改善认知功能。研究OC 与认知功能障碍的关系可能有助于探索认知干预的新方法。 [ABSTRACT FROM AUTHOR]

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